Introduction- Intrauterine fetal death (IUFD) is always a massive psycho-affective trauma for a woman and a couple. The investigation for the cause is essential for improving care by implementing preventative measures. Therefore, this study aimed to assess the major causes of stillbirth. The study was conduc Methods- ted at a tertiary care hospital in Kolhapur at D.Y PATIL HOSPITAL. The hospital records of intrauterine fetal death between clinical duration January 2018 to December 2020 were collected and reviewed and a total of 70 cases with pregnancies of > 28weeks of gestation age, foetus weighing >1000grams and singleton pregnancies were included. Detailed clinical history, examination and laboratory investigations reports were reviewed to analyse the data. In this study Demographics and clinical data were analysed using R-studio software (v.1.2.5001). Of t Result- he 70 cases, high number of women who experienced stillbirth belonged to the age group of 25-30 years (48.57%), had multigravida (70%), female baby (52.86%), term baby (58.57%). Maternal factors causing stillbirths were evident 62.86% of cases. Hypertensive disorder (25.71%), COVID- 19 positive (10%), congenital anomaly (1.43%) were the commonest maternal, placental and fetal causes of fetal death respectively. Maternal and placental causes Conclusionare more commonly resulting in an increased risk of stillbirth. Therefore, health care professionals should identify risk factors in order to prevent stillbirths.
Objective Cervical cancer (CC) is a major public health problem in women, and its early detection can help reduce morbidity and mortality. The objective of this study was to compare serum levels of soluble major histocompatibility complex class I-related chain A (sMICA) levels in various body fluids between women diagnosed with CC and healthy women.Methods A case-control study was conducted at a tertiary care hospital and a cancer center in Kolhapur, India. Overall, 150 individuals (100 CC patients and 50 healthy women) participated after providing informed written consent. Demographic data, histopathology history, parity, and tumor, node, and metastasis (TNM) staging data were collected. Pap smears, saliva, blood, and urine samples were collected. Pap smears were examined microscopically, and sMICA levels in all samples were determined by enzyme-linked immunoassay (ELISA).Results The mean age of women with cervical cancer was 49.86±8.18 years. Squamous cell carcinoma (70%) was the most common histological variant in CC patients. Serum soluble sMICA levels differed significantly with parity and TNM staging (P<0.05). Mean levels of sMICA were significantly different in samples (CC cases vs. healthy patients; saliva: 166.721±108.718 vs. 0.039±0.005 pg/mL; urine: 82.921±45.580 vs. 0.010±0.005 pg/mL; serum: 35.756±10.799 vs. 0.039±0.005 pg/mL, P<0.001).Conclusion Levels of sMICA in body fluids can be considered as a diagnostic or prognostic tool to determine disease progression or tumor regression.
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