A simple and clean asymmetric synthesis of proton pump inhibitors using inexpensive 10-camphorsulfonyl oxaziridine is described. Here, we report the activation of prochiral sulfide by making the DBU salt that is capable of enhancing the reactivity and enantioselectivity.
A safe and inexpensive procedure for asymmetric reduction
of ketones
using in situ prepared N,N-diethylaniline
borane (DEANB) and oxazaborolidine catalyst from sodium borohydride, N,N-diethylaniline hydrochloride and (S)-α,α-diphenylprolinol is described. This protocol
is demonstrated successfully to manufacture enantiopure dapoxetine
at the plant scale.
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