Bacterial meningitis is a common cause of morbidity and mortality in children. The oxidative stress in bacterial meningitis is barely determined. Forty children with bacterial meningitis were studied for their oxidants and antioxidants status in serum and cerebrospinal fluid. Fever (95%) was commonest presentation followed by seizure and vomiting. Neck rigidity and Kernig's sign were present in 37.5% and 27.5% cases, respectively. Plasma and cerebrospinal fluid malondialdehyde, protein carbonyl and nitrite levels were significantly raised in cases (p < 0.001). Plasma and cerebrospinal fluid ascorbic acid, glutathione and superoxide dismutase levels were significantly decreased in children with septic meningitis (p < 0.001). Significantly elevated malondialdehyde, nitrite and protein carbonyl levels reflect increased oxidative stress, whereas decreased concentrations of glutathione, ascorbic acid and superoxide dismutase indicates utilization of the antioxidants in septic meningitis. Thus, changes in oxidants and antioxidants observed suggest production of reactive oxygen species and their possible role in pathogenesis of septic meningitis.
Background: Recent research have found a link between inflammatory pathway and suicidal behaviour. hs-CRP, IL, TNF have been shown to have significant alterations in suicidality, however multiple covariates influence this relationship. One of the main limitations of most of the studies is that they have evaluated the CRP in patients demonstrating suicidal behaviour but not in depression. No study has been conducted in Indian subpopulation with parameters of our study. Aims of the study was to compare hsCRP levels between depression patients with suicidal behaviour and without suicidal behaviour.Methods: Authors compared 50 depression patients with suicidal behaviour and 50 depression patients without suicidal behaviour, diagnosed using ICD10. Hamilton Depression Rating Scale (HDRS‑17), Suicide behaviour Questionnaire- Revised (SBQ-R), Beck Scale for Suicidal Ideation (BSSI) were applied for assessment of depression and suicidality. Highly sensitive CRP was measured using autoanalyzer.Results: hsCRP levels were significantly high in depression patients with suicidal behaviour (4.12 mg/dl) than depression without suicidal behaviour (2.42 mg/dl). Duration of illness, HAM-D, BSSI and SBQ-R scores correlated positively with hsCRP levels.Conclusions: Depression with suicidal behaviour patients have a significantly higher hs-CRP levels than depression without suicidal behaviour. Patients of depression with suicidal behaviour group have a strong positive correlation between hs-CRP levels and HAM-D, BSSI and SBQ-R scores.
Background: Suicidal behaviour is frequently seen in context of depression. Few studies have demonstrated
sociodemographic distinction between depression with and without suicidal behaviour. This study compares various
psycho-socio-demographic factors associated with depression in context of suicidal behaviour.
Materials And Methods: 60 depression patients with suicidal behaviour and 60 depression patients without suicidal behaviour were compared
using a specially designed intake proforma, ICD-10 diagnostic criteria for research,Hamilton Rating Scale for Depression-17 (HAMD-17).
Results: Depression with suicidal behaviour had more females, married, Hindu, literate, low socioeconomic status, urban locality, nuclear family
samples, with earlier age of onset of illness. The total HAM-D scores were signicantly higher in the depression with suicidal behaviour group.
Conclusions: Sociodemographic parameters are intricated crucially with suicidality.The present study identies female gender, nuclear family,
urban background, unemployment and literacy to be an independent risk factor for suicidality. Suicidal behaviour increases with amount of time
spent in depressive illness. Hence socio-demographic factors can be helpful as indicators of suicidal behaviour with depression.
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