A new formamidine-induced translocative rearrangement of 2-pyrone analogs for synthesizing 2-pyridone derivatives with a 1,5-diketo motif was identified. Spectroscopic techniques characterized all the final compounds. In addition, single-crystal X-ray structural studies of two molecules were performed.
Herein, we report a new and cost‐effective methodology for synthesizing N‐substituted 2‐pyridone‐3‐carboxylic acids (2) from 2‐pyrone‐3‐carboxamides (1) with a good yield at room temperature. The notable feature of this reaction is the promotion of amidate ion formation mediated by NaH to initiate intramolecular ring transformation. In addition to ring transformation, simultaneous decarboxylation and substitution under the metal‐free condition in one pot have been achieved to yield N‐substituted 2‐pyridones (3) from 1.
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