We read with interest the recent article by Terpos et al. 1 They reviewed different hematologic findings and complications of COVID-19. Especially, we are interested in lymphopenia in severe COVID-19 patients, which is a predictor factor of severity and mortality. We aimed to report the occurrence of lymphopenia, lymphocyte subsets, and its impact on ICU mortality in critically ill patients with COVID-19. In this single-center cohort, we included adult patients with confirmed COVID-19 infection by a positive reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of a nasopharyngeal swab, admitted in the intensive care unit (ICU) of the Mohammed VIth university hospital of the Marrakech region (Morocco), from March 19, 2020 to May 15, 2020. We collected demographic data, comorbidities, clinical signs at the ICU admission, laboratory findings, chest CT scan if available, outcomes, time from onset of the first symptom to ICU admission, and sequential organ failure assessment (SOFA) scores. We expressed continuous variables as medians and interquartile (IQR) ranges or means (standard deviations (SD)), as appropriate, and compared using independent group Student's t test or the Mann-Whitney U test. Categorical variables were described using percentages and compared using the χ 2-test, although Fisher's exact test was used when the data were sparse. We performed univariable to evaluate the risk factors of mortality. The analysis was processed by spss 10.0 for Windows (SPSS, Chicago, IL, USA). A Pvalue of <.05 was considered statistically significant. Patients CD3+ CD4+ CD8+ CD4+/ CD8+ B cells NK cells Outcome
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