A high-performance liquid chromatographic system using a silica gel column and methylene chloride:methanol:ammonium hydroxide as a solvent for the analysis of some drug substances is described. The procedure described is suitable for the analysis of pharmaceutical dosage forms.
A sensitive and specific method for the determination of quinidine in plasma is described. Quinidine is extracted with chloroform, the extract is evaporated and reconstituted with methanol and the methanol extract is analyzed by high-performance liquid chromatography using a silica gel column. The recovery of quinidine from plasma varied between 93.0 to 100%. Quinidine levels as low as 12 ng/ml can be detected by this method.
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