A multi-component synthesis of 3-(2-amino-4-thiazolyl)coumarins has been reported from 3-(2-bromoacetyl)-2H-chromen-2-ones primary amines and using commercially available trimethylsilyl isothiocyanate. The structures of newly synthesized compounds were characterized by their analytical and spectral data. All the title compounds were screened for antioxidant and anti-inflammatory activity. Among the screened compounds, 4b exhibited highest free radical scavenging activity and also 4b was found to be effective in inhibiting the protein denaturation at all tested concentrations.
A simple and highly efficient one-pot, three-component synthesis of novel substituted imidazole derivatives has been reported by the reaction of 3-(2-bromoacetyl)-2H-chromen-2-one, ammonium thiocyanate, and phenacyl aniline in the presence of acetic acid as a solvent under reflux condition with good yields. The structures of newly synthesized compounds were characterized by their analytical and spectral data. One of these compounds 4a showed good antibacterial activity against Escherichia coli gram-negative strains.
A simple and highly efficient one-amines, and phenyl isothiocyanates in presence of dimethylformamide as a solvent. The structures of newly synthesized compounds were confirmed by their analytical and spectral data.
Synthesis of 3-(2-(4-Chlorophenylimino)-3-(4-chlorophenyl)-2,3-dihydrothiazol--4-yl)-2H-chromen-2-one via MulticomponentApproach. -A one-pot, three--component method for the synthesis of the title compounds is reported. The main advantages are simple reaction conditions, cheap starting materials, an easy work-up as well as a clean reaction profile. -(RAMAGIRI, R. K.; VEDULA*, R. R.; Synth. Commun. 44 (2014) 9, 1301-1306, http://dx.
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