A TMSOTf mediated 5/6-endo-dig reductive hydroamination cascade on internal alkynylamines gave expedient, stereoselective access to pyrrolidine and piperidine derivatives. We also demonstrate that a protecting group on nitrogen has a profound effect on the reactivity as well as diastereoselectivity.
TMSOTf mediated reaction of alkynyl vinylogous carbonates serendipitously gave 1,4-oxazepine and dihydropyran dienes via transposition of ethyl acrylate moiety involving intramolecular cascade Prins type cyclization/retro-oxa-Michael reaction/cycloisomerisation. The developed atom-economical protocol...