Objective
The objective of this systematic review with meta‐analysis was to critically evaluate the available data on sensitivity and specificity of IHC compared with molecular tests in the detection of BRAF V600E mutation in ameloblastomas.
Materials and methods
This systematic review was performed based on the PRISMA statement and registered in Prospero (CRD42021259117). PubMed, Web of Science, Scopus, and Cochrane Library databases were searched for observational studies to answer the question “What is the diagnostic accuracy of immunohistochemistry compared with molecular tests for the diagnosis of BRAF V600E mutation in ameloblastomas?”. Methodological quality and risk of bias assessment of the selected studies were based on the QUADAS‐2. Meta‐analysis based on hierarchical SROC curve model and summary measures for sensitivity and specificity were computed.
Results
A total of 226 records were found, but only 05 articles met the inclusion criteria, with 277 FFPE specimens of ameloblastoma included in the quantitative analysis. The sensitivity of the IHC compared to molecular tests ranged from 0.71 to 1.00, while all of the included studies showed perfect specificity (1.00). Pooled measures for sensitivity and specificity were 0.95 [95% CI 0.89, 1.00] and 1.00 [95% CI 0.95, 1.00], respectively. The diagnostic odds ratio was 4.05, and the AUC for SROC curve was calculated as 0.979.
Conclusions
BRAF V600E‐specific IHC using VE1 antibody showed extremely high sensitivity and specificity when compared with molecular tests in the detection of the mutation in ameloblastomas.
Objective: This study aimed to evaluate the relative prevalence, demographic distribution and clinical-pathological characteristics of the maxillary odontogenics cysts and tumors of the jaws in a pathology laboratory located in a university hospital in Northeastern Brazil. Methods: An observational and retrospective study was carried out, in which information was collected on histopathological diagnosis, age, gender and location of the lesion of patients who had been diagnosed with odontogenic cysts or odontogenic tumors between 2013 and 2020. Results: Among the 546 specimens, 57 were odontogenic cysts and 41 were odontogenic tumors. The most frequent odontogenic cysts were the odontogenic keratocyst 21 (21.4%) and the root cyst 19 (19.4%). The most frequent odontogenic tumors were ameloblastoma 27 (27.6%) and odontoma 6 (6.1%). Conclusion: The data found in this study are possibly associated with the service assistance profile.
Objetivo: Analisar associação entre o bullying com as alterações de peso em adolescentes. Metodologia: Estudo transversal, participaram os adolescentes da rede estadual de ensino de Olinda, entre 14 a 19 anos e ambos os sexos. O instrumento utilizado foi a PeNSe e a avaliação antropométrica. Resultados: Obtiveram-se que para análise do bullying, os adolescentes do sexo masculino (23,1%), entre 14-16 anos de idade (26,3%) e obesos (44%) eram mais acometidos. Dentre as variáveis analisadas, apenas IMC foi estatisticamente significativo para que sofresse bullying escolar. Em se tratando de cyberbullying, a maioria foi do sexo feminino (9,8%), tinha entre 17-19 anos (11,8%) e eram obesos (16%). Diferentemente do bullying, as variáveis analisadas não foram estatisticamente significativas para a prática do cyberbullying. Discussão: Em relação ao sexo, observou-se no presente estudo uma distribuição homogênea entre os sexos feminino e o masculino, em casos tanto de bullying como de cyberbullying. Em relação a idade, ser mais jovem (14-16 anos), é considerado um fator atenuante como aqueles com sobrepeso/obesidade para que se tornem vítimas de bullying, ao contrário do cyberbullying, que teve sua maior parte de jovens entre 17-19 anos. Conclusão: A prática do bullying causa prejuízos à saúde mental e física desses jovens que estão em uma fase de desenvolvimento.
Esta revisão integrativa teve como objetivo avaliar o perfil sociodemográfico e obstétrico das adolescentes em situação de abortamento. Os artigos foram publicados em um período de 10 anos e ao final da busca foram selecionados cinco artigos. O presente trabalho indica que a maioria dos abortos foram provocados, oriundos de gravidez indesejada e na maioria dos casos o ato foi realizado de forma insegura. Por conseguinte, intercorrências e complicações tem mais chance de ocorrer assim colocando em risco a vida da adolescente e aumentando os custos do sistema de saúde.
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