rah & Company LLC. RATIONALE: There is limited data on the effect of the penicillin allergy label (PAL) in pregnancy-related outcomes, including among Group B Streptococcus (GBS)-positive women. METHODS: We performed a retrospective analysis of all deliveries at Rochester Regional Health from 2013-2018. We evaluated the effect of the PAL on GBS colonization, number of C-sections, labor duration, gestational age, maternal and fetal length of stay, neonatal antibiotic therapy, 5 min APGARs, NICU admissions, neonate oxygen therapy, and birthweight. We also examined these same outcomes among only GBSpositive women with and without PAL. A chi square test was used for categorical variables and t-test was used for continuous variables. RESULTS: There were 20,267 live births analyzed, with 18,448 (91%) women without PAL and 1,819 (9%) women with PAL. The median ages of the PAL and non-PAL groups were 32 [interquartile range (IQR) 28-36], and 31 (IQR 27-35), respectively. There were no statistically significant differences between women with and without PAL and their neonates with regards to GBS colonization, number of C-sections, labor duration, gestational age, maternal and fetal length of stay, neonatal antibiotic therapy, 5 min APGARs, NICU admission, neonate oxygen therapy, and birthweight. There were also no differences in the same outcomes in only GBS positive women with and without PAL. CONCLUSIONS: Our analysis did not demonstrate any significant effect of the PAL in pregnancy-related outcomes, including among GBS positive women. These results may be limited by potentially confounding data that we were unable to easily extract from the electronic health record.