Objective:To investigate the association between serum uric acid levels and insulin
resistance in children and adolescents with obesity.Methods:Cross-sectional study with 245 children and adolescents (134 obese and 111
controls), aged 8-18 years. The anthropometric variables (weight, height and waist
circumference), blood pressure and biochemical parameters were collected. The
clinical characteristics of the groups were analyzed by t-test or
chi-square test. To evaluate the association between uric acid levels and insulin
resistance the Pearson's test and logistic regression were applied.Results:The prevalence of insulin resistance was 26.9%. The anthropometric variables,
systolic and diastolic blood pressure and biochemical variables were significantly
higher in the obese group (p<0.001), except for the
high-density-lipoprotein cholesterol. There was a positive and significant
correlation between anthropometric variables and uric acid with HOMA-IR in the
obese and in the control groups, which was higher in the obese group and in the
total sample. The logistic regression model that included age, gender and obesity,
showed an odds ratio of uric acid as a variable associated with insulin resistance
of 1.91 (95%CI 1.40-2.62; p<−0.001).Conclusions:The increase in serum uric acid showed a positive statistical correlation with
insulin resistance and it is associated with and increased risk of insulin
resistance in obese children and adolescents.
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