Background Social networking sites are widely used by university students. This study investigated the purposes for which social networking sites are used and their effects on learning, social interaction, and sleep duration. Material and methods A cross-sectional study was conducted among 300, 17–29-year-old female students at Prince Sattam bin Abdul Aziz University. A questionnaire was used to collect data. Chi-squared (Fisher’s exact test) test was used to analyze the data. Results The results showed that 97% of the students used social media applications. Only 1% of them used social media for academic purposes. Whereas 35% of them used these platforms to chat with others, 43% of them browsed these sites to pass time. Moreover, 57% of them were addicted to social media. Additionally, 52% of them reported that social media use had affected their learning activities, 66% of them felt more drawn toward social media than toward academic activities, and 74% of them spent their free time on social media platforms. The most popular applications (i.e., based on usage) were Snapchat (45%), Instagram (22%), Twitter (18%), and WhatsApp (7%). Further, 46% and 39% of them reported going to bed between 11 pm and 12 am and between 1 am and 2 am, respectively. Finally, 68% of them attributed their delayed bedtime to social media use, and 59% of them reported that social media had affected their social interactions. Conclusions A majority of the participants reported prolonged use of social networking sites for nonacademic purposes. These habitual behaviors can distract students from their academic work, adversely affect their academic performance, social interactions, and sleep duration, and lead to a sedentary lifestyle and physical inactivity, which in turn can render them vulnerable to non-communicable diseases and mental health problems.

Aim: This study investigated the impact of hypertension combined with diabetic nephropathy on rat renal α₁-adrenoceptor subtype composition. Methods: In streptozotocin-induced diabetic spontaneously hypertensive rats (SHR), diabetic nephropathy developed as reflected by increased kidney index, plasma creatinine, albumin excretion, creatinine clearance and fractional excretion of Na⁺ (all p < 0.05). Renal vasoconstrictions caused by electrical stimulation of renal nerves and intrarenally administered noradrenaline (α-adrenoceptor agonist), phenylephrine (α₁-adrenoceptor agonist) and methoxamine (α_1A-adrenoceptor agonist) were determined in the presence and absence of intrarenally administered amlodipine (Ca²⁺ channel blocker), 5-methylurapidil (α_1A-adrenoceptor antagonist), chloroethylclonidine (α_1B-adrenoceptor antagonist) and BMY 7378 (α_1D-adrenoceptor antagonist). Results: In diabetic nephropathy SHR, there was a significant (all p < 0.05) attenuation of all adrenergically induced vasoconstrictor responses in the antagonists, except chloroethylclonidine, which caused a significant (all p < 0.05) enhancement of the responses. Conclusion: The data demonstrated that there was a functional coexistence of α_1A- and α_1D-adrenoceptors in the renal vasculature of SHR irrespective of the presence of diabetic nephropathy. However, there was a minor contribution of pre-synaptic α-adrenoceptors to the adrenergically mediated vasoconstrictor responses in the diabetic nephropathy SHR.

Young generations of Saudi Arabia have adapted a culture of eating fast food items, which are rich in salt. Excess salt intake is a threat to cardiovascular functioning and risk for various cardiovascular diseases. The study, therefore, determines the prevalence and consumption of fast food, the level of physical activity, and the occurrence of hypertension among female students. A cross-sectional study design has been employed to include female students from the College of Arts and Science and Applied Medical Science Wadi Addawasir from January to April 2018. Chi-square/Fisher Exact test has been used for determining the occurrence of categorical variables. The questionnaire was intended to determine fast food habits prevalent among students. 97% of the students consumed fast food daily, 34% of the students were classified as prehypertensive, and 16.4% of the students were classified as hypertensive. Diastolic blood pressure was more compared to systolic blood pressure. Moreover, it was reported that 87% of the students knew the health effects of fast food. 58% of the students were not involved in physical activity and 49% of the students consumed soft drinks along with fast food. 70% of the students used table salt and 57% of the students felt thirsty after fast-food consumption. 55% of the students showed a positive response to the family history of hypertension. The findings have also shown a positive relationship between daily soft drink consumption and the incidence of prehypertension and hypertension among students. Increased consumption of salt-rich fast food, physical inactivity, genetic background of hypertension, prehypertensive and hypertensive conditions observed in the present study may expose to various cardiovascular diseases among the adult population in the future.

1 Increased renal vascular resistance is one renal functional abnormality that contributes to hypertension, and alpha(1)-adrenoceptors play a pivotal role in modulating this renal vascular resistance. This study investigates the functional contribution of alpha(1)-adrenoceptor subtypes in the renal cortical vasculature of Wistar-Kyoto rats on a normal sodium diet (WKYNNa) compared with those given saline to drink for 6 weeks (WKYHNa). 2 The renal cortical vascular responses to the adrenergic agonists noradrenaline (NA), methoxamine (ME) and phenylephrine (PE) were measured in WKYHNa and WKYNNa rats either in the absence (the control phase) or presence of chloroethylclonidine (CEC), an alpha(1B)-adrenoceptor antagonist, 5-methylurapidil (5-MeU), an alpha(1A) antagonist, or BMY7378, an alpha(1D) antagonist. 3 Results showed a greater renal cortical vascular sensitivity to NA, PE and ME in the WKYHNa compared with WKYNNa rats (P < 0.05). Moreover, 5-MeU and BMY7378 attenuated adrenergically induced renal cortical vasoconstriction in WKYHNa and WKYNNa rats; this response was largely blunted in CEC-treated WKYHNa rats (all P < 0.05) but not in CEC-treated WKYNNa rats. 4 The data suggest that irrespective of dietary sodium content, in Wistar-Kyoto rats alpha(1A)- and alpha(1D)-subtypes are the major alpha(1)-adrenoceptors in renal cortical vasculature; however, there appears to be a functional involvement of alpha(1B)-adrenoceptors in the WKYHNa rats.