A simple and efficient protocol for the oxidation of trifluoromethyl, mono- and difluoromethyl sulfides to the corresponding sulfoxides without over-oxidation to sulfones, using TFPAA prepared in situ from trifluoroacetic acid and 15% H2O2 aqueous solution was developed. The methodology is suitable for a wide range of aromatic and aliphatic substrates in milligram and multigram scales.
Sulfonium compounds Q 0585A New Method for the Synthesis of Trifluoromethylating Agents-Diaryltrifluoromethylsulfonium Salts. -Title compounds such as (IV) and (XVI) appear to be useful reagents for the electrophilic trifluoromethylation of various substrates including S-and P-nucleophiles. -(YAGUPOLSKII*, L. M.; MATSNEV, A. V.; ORLOVA, R. K.; DERYABKIN, B. G.; YAGUPOLSKII, Y. L.; J. Fluorine Chem. 129 (2008) 2, 131-136; Inst. Org. Chem., Natl. Acad. Sci. Ukr., Kiev 02094, Ukraine; Eng.) -R. Langenstrassen 20-075
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