Buruli ulcer is a debilitating skin disease caused by the environmental pathogen
Mycobacterium ulcerans
.
M. ulcerans
produces a toxic compound, mycolactone, which leads to tissue necrosis and ulceration. Barriers to preventing Buruli ulcer include an incomplete understanding of
M. ulcerans
reservoirs, how the pathogen is transmitted, and under what circumstances mycolactone and other
M. ulcerans
genes are expressed and produced in its natural environment and in the host.
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