Background:
Diabetes is a multifactorial disease and a major cause for many microvascular
and macrovascular complications. The disease will ultimately lead to high rate mortality if it is not
managed properly. Treatment of diabetes without any side effects has always remained a major challenge
for health care practitioners.
Introduction:
The current review discusses the various conventional drugs, herbal drugs, combination
therapy and the use of nutraceuticals for the effective management of diabetes mellitus. The biotechnological
aspects of various antidiabetic drugs are also discussed.
Methods:
Structured search of bibliographic databases for previously published peer-reviewed research
papers was explored and data was sorted in terms of various approaches that are used for the treatment
of diabetes.
Results:
More than 170 papers including both research and review articles, were included in this review
in order to produce a comprehensive and easily understandable article. A series of herbal and synthetic
drugs have been discussed along with their current status of treatment in terms of dose, mechanism of
action and possible side effects. The article also focuses on combination therapies containing synthetic
as well as herbal drugs to treat the disease. The role of pre and probiotics in the management of diabetes
is also highlighted.
Conclusion:
Oral antihyperglycemics which are used to treat diabetes can cause many adverse effects
and if given in combination, can lead to drug-drug interactions. The combination of various phytochemicals
with synthetic drugs can overcome the challenge faced by the synthetic drug treatment.
Herbal and nutraceuticals therapy and the use of probiotics and prebiotics are a more holistic therapy
due to their natural origin and traditional use.
Microgrids are believed to be the befitting green solution to the ever-rising energy crisis in the developing nations. The resource rich nations are rapidly shifting their dependence on microgrids to meet the reduced carbon footprint target at a global level. This paper addresses this issue and presents a detailed technical review on microgrid integration in competitive electricity market scenario. An in-depth coverage of the need for and importance of microgrid deployments across India is presented in this work. The relevant literature that highlights the significance of various energy storage systems is reviewed. The authors present the perspective of microgrid integration in a competitive market scenario covering both day ahead and real time market scenarios thereby discussing the concept of maximizing social benefit in a grid integrated microgrid framework. This work also focuses on microgrid optimization techniques and outlines a detailed comparison showing merits and demerits of all the techniques implemented by the researchers so far. The authors highlight the fact that green energy holds the potential to not only outgrow the fossil fuels but it shall do so by fetching the requisite economic benefit to the investors as well.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.