In this article, we are concerned with the input-to-state practical stability (ISpS) of nonautonomous nonlinear infinite-dimensional systems. Sufficient conditions of ISpS are provided based on Lyapunov functions and a nonlinear inequality. We characterize ISpS in terms of uniform practical asymptotic gain property. We show that for a class of admissible inputs the existence of an ISpS-Lyapunov function implies the ISpS of a system in Banach spaces. These results are used to study the input-to-state practical stability of a certain class of nonautonomous semilinear evolution equations. Furthermore, we provide a small-gain theorem for nonautonomous nonlinear interconnected systems. An example is used to illustrate the application of the developed method.
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