Multi-component condensation reactions of aldehydes, 2-naphthol and methyl/benzyl carbamate have been done by using magnesium 2,2,2-trifluoroacetate [Mg(OOCCF 3 ) 2 ] as an efficient catalyst. This methodology results in the synthesis of a variety of methyl (2-hydroxynaphthalen-1-yl)(aryl)methyl/benzylcarbamate derivatives in high yields. Despite their importance from pharmacological and synthetic points of view, comparatively few methods for the preparation of 1-carbamatoalkyl 2-naphthol derivatives have been reported via multi-component reactions of aldehydes, 2-naphthol and carbamate using acidic catalysts. Magnesium 2,2,2-trifluoroacetate [Mg(OOCCF 3 ) 2 ] has been prepared from the reaction of trifluoroacetic acid and magnesium chloride. The prepared catalyst has been characterised through a powder X-ray diffraction pattern.
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