Background: Angiogenesis is the process through which new blood vessels are formed from existing ones. This process plays an important role in supplying the oxygen and nutrients needed for cellular metabolism and eliminating cell debris during wound healing. Snail mucus can bind to several factors that stimulate angiogenesis, including vascular endothelial growth factor, platelet-derived growth factor, and fibroblast growth factor. The aim of this study is to observe changes in angiogenesis during the healing of wounds topically applied with snail mucus. Methods: Punch biopsy was performed on the back of male Wistar rats to obtain four wounds, and different concentrations of snail mucus were applied to each of these wounds. The animals were sacrificed on days 2, 4, and 7 to observe the extent of angiogenesis during wound healing by microscopy. Results: Two-way ANOVA showed differences in number of blood vessels formed (p = 0.00) and day of observation (p = 0.00) between groups. Post hoc Tukey’s HSD test showed that 24% snail mucus treatment does not significantly affect wound healing (p = 0.488); by contrast, treatment with 48% and 96% snail mucus demonstrated significant effects on angiogenesis (p = 0.01). Spearman’s test showed interactive effects between snail mucus concentration and day of observation on the extent of angiogenesis (p = 0.001, R = 0.946). Conclusion: Topical application of snail mucus gel can increase angiogenesis during wound healing in Wistar rat skin.
ABSTRAKGigi dikatakan impaksi ektopik apabila mengalami malposisi yang disebabkan oleh faktor kongenital atau mengalami perubahan posisi yang disertai dengan kondisi patologis. Kondisi patologis yang sering menyertai gigi impaksi ektopik adalah kista dentigerous. Tujuan dari studi pustaka ini adalah untuk memaparkan odontektomi pada kasus molar ketiga ektopik yang disertai dengan kista dentigerous. Operasi ini adalah untuk menghilangkan faktor penyebab terjadinya kista dentigerous serta membersihkan lesi kista agar tidak berkembang semakin membesar. Pasien laki-laki 38 tahun mengeluhkan adanya sedikit benjolan pada pipi sebelah kanan namun tanpa disertai rasa sakit. Benjolan dirasakan mulai muncul dalam satu tahun terakhir. Hasil pemeriksaan radiografik menunjukkan gigi molar ketiga mandibula kanan berada pada sudut angulus mandibula disertai adanya gambaran radiolusen pada mahkotanya didiagnosa sebagai impaksi ektopik gigi molar ketiga mandibula kanan disertai kista dentigerous. Tindakan operasi odontektomi dan enukleasi kista dentigerous dilakukan secara ekstraoral dengan anastesiumum, pemilihan metode pengambilan ekstraoral karena posisi gigi yang telah berubah jauh dari posisi normal gigi molar ketiga mandibula. Telah dilakukan pengambilan gigi molar ketiga mandibula yang impaksi ektopik dan enukleasi kista dentigerous secara ekstraoral, karena posisi gigi impaksi yang ektopik di ramus mandibula. Pengambilan gigi impaksi secara ekstraoral sangat jarang sekali dilakukan, namun jika posisi gigi berada jauh sekali dari posisi normal maka pendekatan ekstraoral merupakan metode operasi yang akan mempermudah proses pengambilan gigi dan enukleasi kista serta dapat meminimalkan hilangnya tulang mandibula yang sehat. MKGK. Desember 2015; 1(2): 85-91Kata kunci: impaksi ektopik, kista dentigerous, enukleasi ekstraoral ABSTRACT: Odontectomy of Ectopic Third Molar Associated with Dentigerous Cyst in Submandibular Region. Ectopic impacted tooth has been defined as malpositioned tooth caused by congenital factor or malpositioned tooth associated with pathologic condition. Pathologic condition associated with ectopic impacted tooth is dentigerous cyst. The purpose of this operation is to eliminate the causes of the dentigerous cyst and to raise cyst lesions that do not develop as they grow. A 38- PENDAHULUANOdontektomi adalah istilah suatu cara yang digunakan untuk mengambil gigi yang tidak erupsi dan gigi yang erupsi sebagian atau sisa akar yang tidak dapat diekstraksi dengan teknik biasa. Pada kasus odontektomi harus dilakukan pembedahan, pengeluaran gigi yang erupsi sebagian atau akar yang kuat yang tidak dapat dicabut dengan metode pencabutan tertutup, sehingga harus dikeluarkan secara bedah atau pencabutan dengan metode terbuka. 1,7 Gigi molar ketiga bawah merupakan gigi yang sangat sering muncul dalam keadaan impaksi, pada kasus ini pencabutan gigi perlu dilakukan dengan metode operasi pembedahan. Klinisi dokter gigi biasanya menerima kasus impaksi atau ektopik yang tidak ada penyebabnya. Faktor-faktor umum yang m...
Background: Angiogenesis is the process through which new blood vessels are formed from existing ones. This process plays an important role in supplying the oxygen and nutrients needed for cellular metabolism and eliminating cell debris during wound healing. Snail mucus can bind to several factors that stimulate angiogenesis, including vascular endothelial growth factor, platelet-derived growth factor, and fibroblast growth factor. The aim of this study is to observe changes in angiogenesis during the healing of wounds topically applied with snail mucus. Methods: Punch biopsy was performed on the back of male Wistar rats to obtain four wounds, and different concentrations of snail mucus were applied to each of these wounds. The animals were sacrificed on days 2, 4, and 7 to observe the extent of angiogenesis during wound healing by microscopy. Results: Two-way ANOVA showed differences in number of blood vessels formed (p = 0.00) and day of observation (p = 0.00) between groups. Post hoc Tukey’s HSD test showed that 24% snail mucus treatment does not significantly affect wound healing (p = 0.488); by contrast, treatment with 48% and 96% snail mucus demonstrated significant effects on angiogenesis (p = 0.01). Spearman’s test showed interactive effects between snail mucus concentration and day of observation on the extent of angiogenesis (p = 0.001, R = 0.946). Conclusion: Topical application of snail mucus gel can increase angiogenesis during wound healing in Wistar rat skin.
ABSTRAKTrauma gigi anak merupakan kasus yang sering dijumpai. Intrusi gigi merupakan salah satu akibat trauma berupa perpindahan gigi ke dalam soket alveolaris. Intrusi gigi permanen anak dengan pertumbuhan akar sempurna perlu segera ditangani untuk menghindari kerusakan permanen gigi dan jaringan pendukung. Reposisi secara bedah dipilih dengan pertimbangan kondisi umum, lama kejadian, keparahan dislokasi, kondisi mahkota dan pertumbuhan akar. Tujuan laporan ini adalah melaporkan keberhasilan pembedahan pada kasus fraktur dentoalveolar dengan multipel gigi intrusi. Seorang anak laki-laki berusia 10 tahun datang ke RSGM Prof. Soedomo dengan keluhan gigi masuk ke langit-langit setelah terjatuh kurang lebih 30 menit sebelum kedatangan. Keadaan umum baik, compos mentis, GCS 15, tanda vital normal, rasa sakit pada gigi atas (VAS = 7), tidak dicurigai cedera kepala atau trauma di tempat lain. Pemeriksaan klinis menunjukkan vulnus laceratum pada gingiva anterior maksila, empat gigi incisivus maksila (12,11, 21, 22) mengalami intrusi. Gigi insisivus sentral dan lateral kanan terlihat sepertiga mahkota, gigi insisivus sentral dan lateral kiri mahkota tidak tampak. Pemeriksaan radiografis menunjukkan intrusi gigi insisivus maksila dengan kedalaman lebih dari 7 milimeter, akar gigi telah tumbuh sempurna, dan tidak terdapat fraktur akar, fraktur mahkota maupun fraktur rahang. Tindakan yang dilakukan adalah reposisi gigi intrusi dan fiksasi interdental maksila. Perawatan bedah dan fiksasi interdental memberikan hasil yang sangat baik. Hasil kontrol pasca perawatan didapatkan oklusi normal, pasien mampu membuka dan menutup mulut tanpa ada gangguan, gigi-gigi intrusi dalam kondisi vital, mastikasi normal, dan estetika baik.Maj Ked Gi; Desember 2013; 20(2): 155 -160. (12,11, 21, 22 Kata kunci: trauma, intrusi, reposisi bedah ABSTRACT: Severe Traumatic Intrusions of Multiple Maxillary Incisors In Children. Dental trauma is one of the most common traumas during childhood. The report will discuss about a treatment of multiple severe traumatically intruded maxillary incisors in children. A 10-year-old boy came to Prof. Soedomo Dental Hospital with a complaint of teeth intrusion after having accident in school thirty minutes before. The patient was in good general condition, compos mentis, the GCS score was 15, vital sign was normal, pain on anterior maxillary teeth (VAS was 7), no head injury or other traumas. The clinical examination showed that there was vulnus laceratum on maxillary gingival, and intrusion of the four maxillary incisors
Management of mandibular fracture using open reduction Internal fixation (ORIF) method is one of the ideal treatments for single and multiple mandibular fractures. The aim of this study was to determine the quality of life of patients after the treatment of mandibular fractures with ORIF using miniplate in single and multiple mandibular fractures. This research used case-control by recalling 43 research subjects in the oral surgery department Dr Sardjito general hospital between 2013 and 2017, that consisted of patients suffering from 23 single fractures and 20 multiple mandibular fractures. Each fracture would be examined clinically and subjectively. Clinical examination parameters were conducted using the mandibular mobility index (MMI) consisting of mouth opening assessment, left and right lateral mandibular excursion, and mandibular protrusive movement. Subjective parameters were performed based on general oral health asseesment index (GOHAI) questionnaire to assess physiological aspects, psychosocial aspects, and pain. The results of the chi-square test statistic study showed that the quality of life of a patient with a single mandibular fracture was better than that of multiple mandibular fractures based on MMI and GOHAI examinations. It was concluded that patients with a single mandibular fracture had a younger age, longer time adaptation and have a better quality of life.
Background: Recurrent ameloblastoma can occur after radical treatment, 13.3% up to 19% involves soft tissue. Case of recurrent mandibular ameloblastoma in soft tissue, bleeding is one of the risks that often occurs. One way to reduce intraoperative bleeding is by embolization. Purpose this studi to report the benefits of embolization to reduce intraoperative bleeding in the action of recurrent ameloblastoma in soft tissue. Method: Female patient 32 years old came to RSUP Dr. Sardjito with complaint of lump on her left cheek, with history of post-hemimandibulectomy ameloblastoma 14 years ago. Objective examination of the asymmetrical patient's face with swelling extends to the cheek and pain when pressed, and the size is around 10x10 cm. Embolization using PVA and gelfoam material done before the excision of the tumor to reduce the risk of bleeding. The excision in this case is using lip split method, with bleeding during surgery around 250 ml. Biopsy results after excision are multicystic ameloblastoma, some are follicular types and some are plexiform types Conclusion: The use of embolization in the case of recurrent mandibular ameloblastoma in soft tissue can reduce tumor size and reduce bleeding during surgery.
ABSTRAKImpaksi kaninus memiliki prevalensi tinggi setelah impaksi molar ketiga. Impaksi kaninus atas terjadi 2 kali lebih banyak pada anak perempuan daripada laki-laki. Inklinasi letak gigi terhadap garis median wajah lebih dari 45 0 memiliki prognosis jelek untuk erupsi. Tujuan laporan kasus ini adalah memberikan informasi penatalaksanaan impaksi kaninus kiri atas pada anak dengan pembedahan. Kasus ini dilaporkan pada anak perempuan usia 12,5 tahun yang datang di klinik Kedokteran Gigi Anak RSGM Prof Soedomo dengan keluhan utama seringkali sakit kepala sisi kiri serta gigi 23 belum erupsi. Berdasarkan anamnesis, pemeriksaan klinis dan radiologis tampak gigi 23 posisinya horisontal, perlu dilakukan odontectomy dengan metode in toto. Gigi 63 dipertahankan karena tidak ada luksasi. Traksi secara ortodontik pada pasien ini tidak dilakukan karena letak gigi 23 dalam dan posisinya horisontal. Kesimpulan laporan kasus ini adalah impaksi gigi 23 dengan posisi horizontal kemungkinan dapat menimbulkan sakit kepala. Odontectomy gigi 23 berhasil dengan baik melalui pembuatan flap envelope dan penjahitan interrupted. Kontrol pada hari ke-7 dan setelah 1 bulan, pasien tidak mengeluhkan sakit kepala sisi kiri. MKGK. Desember 2015; 1(2): 92-98Kata kunci: Impaksi kaninus kiri rahang atas, odontectomy, anak-anak. ABSTRACT: Management of Horizontally Impacted Maxillary Left Canines in Children. Impacted canines have a high prevalence after impacted third molar. Impacted maxillary canines occur twice more often in female children than male ones. The location of the tooth inclination towards the midline of the face which is more than 450 has a poor prognosis for eruption. The purpose of this case report is to provide information of surgical management of impacted maxillary left canines in children PENDAHULUANGigi impaksi adalah gigi yang gagal erupsi ke dalam lengkung rahang pada kisaran waktu yang diperkirakan. Suatu gigi mengalami impaksi akibat dari kekurangan ruang, lapisan tulang yang padat atau jaringan lunak yang tebal, infeksi kronis, dan kelainan tumbuh kembang gigi. 1 Jalan erupsi yang salah dari gigi permanen, kemungkinan besar disebabkan oleh kegagalan resorpsi gigi desidui sehingga terjadi persistensi dan dapat menimbulkan kegagalan erupsi gigi permanen sehingga gigi menjadi impaksi. 2 Pada umumnya gigi mengalami impaksi akibat panjang lengkung gigi yang tidak dapat menampung gigi dan panjang lengkung gigi yang lebih kecil daripada panjang total mesiodistal gigi. Gigi-geligi yang seringkali mengalami impaksi adalah gigi molar tiga rahang atas dan bawah, gigi kaninus rahang atas dan premolar rahang bawah. 3 Banyaknya kasus impaksi kaninus sebesar 0,8-2,8 persen. 4 Gigi kaninus merupakan gigi kedua setelah gigi molar ketiga yang sering mengalami impaksi, meskipun demikian gigi anterior di rahang atas lainnya seperti gigi insisivus pertama dan kedua rahang atas juga dapat mengalami impaksi karena kesalahan posisi di dalam rahang. 5 Impaksi kaninus rahang atas terjadi 2 kali lebih banyak pada
Objective: To evaluate the effects of 15 mg meloxicam administered 60 minutes before odontectomy on pain, facial edema, trismus and expressions of TNF-α after odontectomy of impacted mandibular third molar. Material and Methods: A total of 24 patients were randomized into treatment groups, each with 12 patients: Group A was administered with 15 mg of meloxicam; and Group B with placebo. Drugs were administered orally 60 minutes prior to surgery. Observation of pain (seen from VAS scores), facial edema (seen from swollen cheeks), trismus (seen from mouth opening) and expressions of TNF-α (measured from saliva by ELISA method), performed before odontectomy, H+1 (24 hours after odontectomy) and H+3 (72 hours after odontectomy).Results: Patients who received 15 mg meloxicam 60 minutes before odontectomy showed less postoperative pain (p=0.000), less facial edema (p=0.000) and lower expressions of TNF-α (p=0.000). No differences were found in mouth opening between the meloxicam group and placebo group (p=0.522). The higher level of TNF-α level will lead to higher level of pain, greater facial edema and causes smaller mouth opening. Conclusion: Oral administration of 15 mg meloxicam 60 minutes prior to odontectomy was found more effective in reducing pain, facial edema and expressions of TNF-α after odontectomy of impacted mandibular third molar compared with placebo.
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