BACKGROUND Gastric Outlet Obstruction (GOO) also known as pyloric obstruction is not a single entity. It is the clinical and pathophysiological consequence of any disease process that produces a mechanical impediment to gastric emptying. Aim-To study various diseases presenting as gastric outlet obstruction in Krishna Rajendra Hospital, Mysore attached to Mysore Medical College and Research Institute, Mysore. MATERIALS AND METHODS The patients for this study have been selected from Krishna Rajendra Hospital, Mysore attached to Mysore Medical College and Research Institute, Mysore during the time period of August 2016 to August 2018. Overall, 64 patients have been studied. An elaborate study of the cases with regard to history, clinical features, routine and special investigations, pre-operative treatment, operative findings, post-operative management and complications in the post-operative period is done. Apart from routine surgical profile special investigations like serum electrolytes, barium meal study, upper GI endoscopy and ultrasound abdomen and pelvis were carried out. RESULTS Out of the 64 cases included in our study, 32 patients (50%) had carcinoma of pyloric antrum, 26 patients (40.6%) had cicatrised duodenal ulcer, 4 patients (6.25%) had corrosive antral stricture and 2 patients (3.125%) had gastric outlet obstruction due to carcinoma head of pancreas. CONCLUSION The following conclusions were made in our study:-1. Carcinoma of the antrum of stomach was the commonest cause for Gastric Outlet Obstruction; 2. Age incidence varies between 51-60 years. Patients of 5th and 6th decades were the commonest victims; 3. Slight male predominance was observed in our study; 4. Vomiting was the commonest presentation of Gastric Outlet Obstruction; 5. UGI scopy was invaluable in diagnosing the aetiology of Gastric Outlet Obstruction.
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