PURPOSE:Genetic factor to bitter taste perception appears to be largely mediated by the TAS2R38 gene. The insensitivity to bitter compounds like 6-n-propylthiouracil (PROP) is mediated by this gene. PROP, a pharmacological drug used in treatment of Graves’ disease, proved to be useful tool in determining the genetic sensitivity levels to bitter and sweet taste. The purpose of this study is to show much simpler PROP sensitivity technique for the clinical examiner and its application as a diagnostic aid in Early Childhood Caries (ECC) detection among preschool children.MATERIALS AND METHODS:A total of 119 children belonging to the age group of 36 to 71 months of both sexes, were recruited from A. J. Institute of Dental Sciences, Mangalore (Karnataka). PROP sensitivity test was carried out to determine the inherent genetic ability to taste a bitter or sweet substance. This study used simpler scaling method to find out genetic sensitivity to bitter taste; one who tasted bitter as taster and one who was not able to differentiate/tasted like paper as non-taster. A questionnaire was provided to evaluate their dietary habits and caries experience was recorded. Collected data were tabulated and subjected to statistical analysis.RESULTS:In the total of 119 children the mean dmfs was definitely higher in non-taster children compared to tasters. The tasters had a mean dmfs value of 9.5120 (S.D. 7.0543) and non-tasters had a value of 7.7250 (S.D. 8.33147), which was statistically significant. The results suggested that there was increase in caries experience among the group of non-tasters as compared to tasters. Tasters tended to be sweet dislikers and non-tasters tended to be sweet likers. On the whole, tasters had a bad dentition as compared to non tasters.CONCLUSION:The PROP sensitivity test (filter paper test) proved to be a useful diagnostic tool in determining the genetic sensitivity levels of bitter taste. The knowledge of a child's taste perception can help us in identifying the children who are at higher risk for ECC.
Treacher Collins syndrome (Mandibulofacial dysostosis) is characterized by deafness, hypoplasia of facial bones (mandible, maxilla and cheek bone), antimongoloid slant of palpebral fissures, coloboma of the lower lid and bilateral anomalies of the auricle. Hypoplasia of the facial bones may be the first indicator of the disorder. We present a case report of Treacher Collins syndrome with their extraoral findings, intraoral findings and their treatment plan. We have also included the various etiological factors, clinical diagnostic aids, and multidisciplinary team approach.
Objectives: This study estimated the prevalence of early childhood caries (ECC) and related risk factors in a population of immigrant Tibetan preschool children in Bylakuppe of Mysore District; India. Methodology: A cross sectional study was conducted in 500 preschool children between 10 to 72 months of age in and around Bylakuppe of Mysore district; India; using II stage stratified random sampling. The caries experience was recorded using defs and the deft index. Information regarding risk factors for caries was obtained through a structured questionnaire given to mothers/caretakers. Statistical data analysis: The data was statistically analyzed by using "chi-square" test and "ANOVA" test. Results: The prevalence of ECC in the study sample was significantly high. It was 92.2% with the mean defs score of 10.27 and the mean deft score of 6.15 (p<0.001vhs).Higher prevalence of ECC was found, in children with bottle feeding, addition of sugar to bottle content and to regular food, in-between meal snacking habits and increase intake of sweets like chocolate, candies and toffees, lesser frequency of brushing and child brushing unassisted/unsupervised. Reports of regular visits to the dentist were almost absent in the study population. Conclusion: This study demonstrates the high prevalence of ECC in the study population. Development of strategies and protocols; to prevent and manage ECC, based on the risk factors identified for these population, is essential to curb this oral health problem.
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