Development of efficient fluorescent organic nanoparticles (FONs) for in vitro andi nv ivo bioimaging is one of the emerging areas of nanobiotechnology.H ere, we report the synthesis of an ovel fluorescent chromophore, composed of ac ytosine moiety connected to am odified 2,1,3-benzothiadiazole fluorescent tag by an aliphatic chain. Self-assembly of the molecules in DMSO/H 2 Os olution led to the formation of solution-stable, red emissive, biocompatible, nontoxic nanoparticles (nano-Cy-Red). These nanoparti-cles werebiocompatible and safe forall the tested biological organisms; the staining protocol was also simple andr apid. Nano-Cy-Red exhibited the ability to penetrate into mouse macrophages, cancer cells, and yeasta nd was retained in living cells for several generations serving as ac ytoplasmic stain. Taking advantage of this property,w ee xploit the nano-Cy-Red dye for directi nv ivo visualization of cancer cell migration up to 72 hp ostt ransplantation in zebrafish embryos.[a] E. R. Reddy,D r. M. Rajadurai
The Inside Cover shows the in vitro and in vivo applications of red fluorescent organic nanoparticles (FONs): illuminating the cytoplasm of cultured cells, visualizing yeast septa, and tracking the migration of transplanted cancer cells in zebrafish embryos. Solution‐stable, red‐emissive, biocompatible, nontoxic nanoparticles (nano‐Cy‐Red) were prepared via self‐assembly of a novel fluorescent chromophore, composed of a cytosine moiety connected to the 2,1,3‐benzothiadiazole fluorescent tag by an aliphatic chain. More information can be found in the Full Paper by M. Rajadurai et al. on page 567 in Issue 8 2015 (DOI: 10.1002/cnma.201500108).
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