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To investigate the incidence and accountable factors for the potential dropout thoughts among Saudi medical students. A cross-sectional survey questionnaire based study was conducted among Saudi medical students enrolled at the College of Medicine, King Saud University. A total number of 587 (39.13%) medical students out of ∼1,500 filled the questionnaire. Among them 302 (51.4%) reported incidence(s) of dropout thoughts at least once. However, only 17 (5.6%) have thought of dropping out very seriously. The majority of the students (67.5%) thought for withdrawal only on stressful days. The first year of the medical school was the most common year for all the students (49.3%) for thinking of dropout and academic problems were the most common reasons behind dropout thoughts (37.8%). The students, whose decision for entering in the medical school was influenced by the surroundings were at higher risk of dropout thoughts than their peers ( OR = 1.912, CI 1.33–2.75). A significant amount of dropout thoughts was prevalent among Saudi medical students, but serious thinker about dropout were less in numbers. A well-structured academic guidance program supported with psychological teaching method must be designed and offered to diagnose the symptomatic students before actually they get affected with dropout thought which might lead to actual dropout.

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Background Diabetic ketoacidosis (DKA) is one of the most common admission diagnoses to the intensive care unit (ICU). This study aims primarily to identify the rate of DKA-related ICU admission, and to assess the possible leading risk factors. Secondarily, to assess the rate of ICU readmission and mortality. Methods This retrospective observational study took place in King Abdulaziz University Hospital and collected data from January 2018 till December 2020. Patients aged 15 years and older with DKA Related-ICU admissions were included. Association between variables such as, demographics, precipitating factor, biochemical data, ICU stay details. History of readmission, arising complications within the study period were collected. Mortality cases were identified and the direct cause of death was investigated. Statistical analysiswas performed using the SPSS program version 25. Qualitative data were expressed as numbers and percentages, and quantitative data were expressed as mean and standard deviation. Linear regression analysis was used to adjust for the predictors and their association with the admission to the ICU. Result: ICU admissions were 28.4% of all DKA-related admissions (50 out of 176 patients), with a female predominance of 52%. Median length of ICU stay was 3 days. Medications nonadherence was the leading precipitating factor for ICU admission in 50% of the patients. Factors significantly associated with risk of ICU admission were on bivariate analysis: pH level of <7.0 (p =0.001), and Patients of >60 years as they had 4 times more risk of ICU admission compared to 15-20 years age group (P=0.04). Nine patients died, but none of them died primarily from DKA as the main cause of death was the DKA precipitating factor. Six patients were readmitted to the ICU (12%) during the study period, the mean duration between the two admissions was 19.74± 26.57 weeks. Conclusion Our findings highlight that nonadherence to medications is the most common precipitating factor to ICU-related DKA admission. Thus, educating patients and early dentification of patients at risk are crucial. Presentation: Sunday, June 12, 2022 12:30 p.m. - 2:30 p.m.

Cardiac glycosides, including digitalis and digoxin, have long-standing use in clinical practice. Digoxin has a half-life that varies from 36 to 48 hours, which may increase in cases of renal failure. Approximately 1% of Congestive Heart Failure patients treated with digoxin develop toxicity. The clinical features of toxicity are often non-specific. Diagnosis is difficult and usually made clinically, as levels of digoxin in the blood do not necessarily correlate with toxicity. Treatment involves early recognition and the administration of antibodies specifically against digoxin also known as Fab fragments. Digoxin concentration does not necessarily correlate with clinical symptoms of toxicity however digoxin concentrations may be used for calculating the amount of antidote therapy. Digoxin-specific antibody fragments are used when there is a risk of a life-threatening arrhythmia.

Background: Bleeding Worldwide, approximately 300,000 infants are born annually with neural tube defects (NTDs), which carry a high risk of morbidity and mortality. Objective: The aim of the study was to describe the experience with NTD patients born at a tertiary academic center. Methods: A retrospective record review of all neonates with NTD admitted to the neonatal intensive care unit over six years. Results: Out of the 39 patients identified, 32 (82.1%) were diagnosed antenatally. Most NTD cases were of the myelomeningocele 26 (66.7%) type. The most common site of the myelomeningocele was lumbar, and the thoracolumbar site had the worst prognosis.Conclusion: Early detection of the disease allows better planning of delivery and treatment decisions. Nevertheless, understanding the magnitude of the problem necessitates adopting public health prevention strategies for better outcomes.

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