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Activation of the amino acid starvation response (AAR) increases lifespan and acute stress resistance as well as regulates inflammation. However, the underlying mechanisms remain unclear. Here, we show that activation of AAR pharmacologically by Halofuginone (HF) significantly inhibits production of the proinflammatory cytokine interleukin 1β (IL-1β) and provides protection from intestinal inflammation in mice. HF inhibits IL-1β through general control nonderepressible 2 kinase (GCN2)–dependent activation of the cytoprotective integrated stress response (ISR) pathway, resulting in rerouting of IL-1β mRNA from translationally active polysomes to inactive ribocluster complexes—such as stress granules (SGs)—via recruitment of RNA-binding proteins (RBPs) T cell–restricted intracellular antigen-1(TIA-1)/TIA-1–related (TIAR), which are further cleared through induction of autophagy. GCN2 ablation resulted in reduced autophagy and SG formation, which is inversely correlated with IL-1β production. Furthermore, HF diminishes inflammasome activation through suppression of reactive oxygen species (ROS) production. Our study unveils a novel mechanism by which IL-1β is regulated by AAR and further suggests that administration of HF might offer an effective therapeutic intervention against inflammatory diseases.

Security is one of the most critical aspects of software quality. Software security refers to the process of creating and developing software that assures the integrity, confidentiality, and availability of its code, data, and services. Software development organizations treat security as an afterthought issue, and as a result, they continue to face security threats. Incorporating security at any level of the Software Development Life Cycle (SDLC) has become an urgent requirement. Several methodologies, strategies, and models have been proposed and developed to address software security, but only a few of them give reliable evidence for creating secure software applications. Software security issues, on the other hand, have not been adequately addressed, and integrating security procedures into the SDLC remains a challenge. The major purpose of this paper is to learn about software security risks and practices so that secure software development methods can be better designed. A systematic literature review (SLR) was performed to classify important studies to achieve this goal. Based on the inclusion, exclusion, and quality assessment criteria, a total of 121 studies were chosen. This study identified 154 security risks and 424 best practices that help software development organizations to manage the security in each phase of the SDLC. To pursue secure SDLC, this study prescribed different security activities, which should be followed in each phase of the SDLC. Successful integration of these activities minimizing effort, time, and budget while delivering secure software applications. The findings of this study assist software development organizations in improving the security level of their software products and also enhancing their security efficiency. This will raise the developer's awareness of secure development practices as well.

and the Ministry of Education Malaysia (MoE) and conducted in collaboration with the Research Management Center (RMC) at Universiti Teknologi Malaysia (UTM) under vot number: Q.J130000.2428.03G94.

Light-responsive nanoliposomes are being reported to induce cancer cell death through heat and reactive oxygen species (ROS).

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