Objetivos. Mostrar la utilidad de un modelo eficaz y oportuno de información y llamar la atención acerca de la gravedad del problema de los homicidios, así como demostrar la necesidad de mantener este tipo de modelo y de sostener proyectos preventivos integrales, como el Programa Desarrollo, Seguridad y Paz (DESEPAZ (OR: 3,1; IC95%: 2,6 a 3,6). En los casos que ocurrieron durante una riña personal o de grupo se observó su asociación con el uso de un arma cortopunzante y con el consumo de bebidas alcohólicas por parte de la víctima (OR: 1,9; IC95%: 1,6). Conclusiones. Se presenta un mapa de la distribución de los homicidios por barrio y se comentan los beneficios del modelo de vigilancia de base poblacional, en especial su valor para identificar los factores de riesgo y las medidas para prevenir y controlar este tipo de violencia.

A deletion of the long arm of chromosome 20 [del(20q)] is a recurring abnormality in a wide spectrum of myeloid disorders. Loss of genetic material from 20q may confer a proliferative advantage to myeloid cells, possibly through loss of function of a tumor suppressor gene. Previously, we analyzed leukemia cells from 19 patients with a del(20q) by fluorescence in situ hybridization (FISH) and identified a segment that was deleted in 95% of all patients examined. The deleted interval extended from 20q11.2 to q12, spanned approximately 13 Mb, and was flanked proximally by RPN2 and distally by D20S17. To narrow the commonly deleted segment and facilitate the identification of candidate genes, we have employed molecular approaches in combination with FISH. By using 21 microsatellite markers positioned in a recently generated physical map of 20q, we performed allele loss studies in myeloid leukemia cells from 23 patients with a del(20q). The results of these studies allowed us to delineate a new proximal border, flanked by marker D20S206. By FISH analysis of additional leukemia samples from patients with a del(20q), we have also delineated a new distal boundary between markers D20S119 and UT654. As a result of the redesignation of both the proximal and distal boundaries, we have successfully narrowed the commonly deleted segment within 20q12 to a region spanning approximately 8 Mb. Identification of the smallest deleted segment will facilitate the eventual cloning of a candidate myeloid tumor suppressor gene.

Objective. To develop a domestic violence surveillance system. Material and Methods. The strategies included implementation of a standard digitalized reporting and analysis system along with advocacy with community decision makers, strengthening inter-institutional attention networks, consultation for constructing internal flow charts, sensitizing and training network teams in charge of providing health care in cases of domestic violence and supporting improved public policy prevention initiatives. Results. A total of 6 893 cases were observed using 2004 and 2005 surveillance system data. The system reports that 80% of the affected were women, followed by 36% children under 14 years. The identified aggressors were mainly females' partners. The system was useful for improving victim services. Conclusions. Findings indicate that significant gains were made in facilitating the attention and treatment of victims of domestic violence, improving the procedural response process and enhancing the quality of information provided to policy-making bodies.

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