Background: Legume lectins with new glycan specificity can be discovered in the Dalbergieae tribe. Results: We determined the sequence, specificity, and crystal structures of a new Man/Glc lectin (PELa) from Platypodium elegans seeds. Conclusion: The unusual affinity of PELa for asymmetrical complex N-glycans is related to the extended binding site and conformational constraints on oligosaccharides. Significance: Dalbergieae lectins are of interest for biotechnological applications.
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