ObjectiveTo assess the effects of postconditioning remote in ischemia-reperfusion injury in
rat lungs.MethodsWistar rats (n=24) divided into 3 groups: GA (I/R) n=8, GB (R-Po) n=8, CG
(control) n=8, underwent ischemia for 30 minutes artery occlusion abdominal aorta,
followed by reperfusion for 60 minutes. Resected lungs and performed histological
analysis and classification of morphological findings in accordance with the
degree of tissue injury. Statistical analysis of the mean rating of the degree of
tissue injury.ResultsGA (3.6), GB (1.3) and CG (1.0). (GA GB X P<0.05).ConclusionThe remote postconditioning was able to minimize the inflammatory lesion of the
lung parenchyma of rats undergoing ischemia and reperfusion process.
CA 549 is one of several carcinoma associated mucin antigens proposed as a breast cancer tumor marker. In this study, the performance characteristics of the CA 549 assay were validated and the clinical utility of the test was compared with that of other breast cancer markers including CA 15-3, CA M26, CA M29 and carcinoembryonic antigen. The upper limit of normal was established as 15.5 U/ml based on data for 250 control subjects apparently free of disease. Overall, CA 549 had a low negative predictive value (0.51) due to a low sensitivity in the detection of early breast cancer. However, the test had a high positive predictive value (0.93) reflecting a high specificity for the disease. In 56 patients with advanced breast cancer, the sensitivity was 0.71 for CA 549 alone and 0.79-0.84 for CA 549 combined with any of the other markers studied.
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