We report on the suitability of core/shell nanoparticles (NPs) for magnetic fluid hyperthermia in a selfregulated and theranostic approach. Aqueous magnetic colloids based on core/shell ZnxMnyFezO4@γ-Fe2O3 and ZnxCoyFe-zO4@γ-Fe2O3 NPs were produced by a three-step chemical synthesis. Systematic deviations from stoichiometry was observed with increasing Zn substitution for both series of samples. We investigated how the chemical composition affects saturation magnetization, magnetic anisotropy and thermomagnetic properties of these core/shell NPs. The heating efficiency through specific power absorption (SPA) was analyzed in the framework of the linear response theory. SPA values obtained for NPs presenting different contrast of anisotropy between the core and shell materials indicate no evidence of enhanced exchange coupling contribution to the heating efficiency.
The Seebeck and Soret coefficients of ionically stabilized suspension of maghemite nanoparticles in dimethyl sulfoxide are experimentally studied as a function of nanoparticle volume fraction. In the presence of a temperature gradient, the charged colloidal nanoparticles experience both thermal drift due to their interactions with the solvent and electric forces proportional to the internal thermoelectric field. The resulting thermodiffusion of nanoparticles is observed through forced Rayleigh scattering measurements, while the thermoelectric field is accessed through voltage measurements in a thermocell. Both techniques provide independent estimates of nanoparticle's entropy of transfer as high as 82 meV K(-1). Such a property may be used to improve the thermoelectric coefficients in liquid thermocells.
Thermodiffusion of different ferrite nanoparticles (NPs), ∼10 nm in diameter, is explored in tailor-made aqueous dispersions stabilized by electrostatic interparticle interactions. In the dispersions, electrosteric repulsion is the dominant force, which is tuned by an osmotic-stress technique, i.e. controlling of osmotic pressure Π, pH and ionic strength. It is then possible to map Π and the NPs' osmotic compressibility χ in the dispersion with a Carnahan-Starling formalism of effective hard spheres (larger than the NPs' core). The NPs are here dispersed with two different surface ionic species, either at pH ∼ 2 or 7, leading to a surface charge, either positive or negative. Their Ludwig-Soret ST coefficient together with their mass diffusion Dm coefficient are determined experimentally by forced Rayleigh scattering. All probed NPs display a thermophilic behavior (ST < 0) regardless of the ionic species used to cover the surface. We determine the NPs' Eastman entropy of transfer and the Seebeck (thermoelectric) contribution to the measured Ludwig-Soret coefficient in these ionic dispersions. The NPs' Eastman entropy of transfer ŝNP is interpreted through the electrostatic and hydration contributions of the ionic shell surrounding the NPs.
The heat produced by magnetic nanoparticles,
when they are submitted
to a time-varying magnetic field, has been used in many auspicious
biotechnological applications. In the search for better performance
in terms of the specific power absorption (SPA) index, researchers
have studied the influence of the chemical composition, size and dispersion,
shape, and exchange stiffness in morphochemical structures. Monodisperse
assemblies of magnetic nanoparticles have been produced using elaborate
synthetic procedures, where the product is generally dispersed in
organic solvents. However, the colloidal stability of these rough
dispersions has not received much attention in these studies, hampering
experimental determination of the SPA. To investigate the influence
of colloidal stability on the heating response of ferrofluids, we
produced bimagnetic core@shell NPs chemically composed of a ZnMn mixed
ferrite core covered by a maghemite shell. Aqueous ferrofluids were
prepared with these samples using the electric double layer (EDL)
as a strategy to maintain colloidal stability. By starting from a
proper sample, ultrastable concentrated ferrofluids were achieved
by both tuning the ion/counterion ratio and controlling the water
content. As the colloidal stability mainly depends on the ion configuration
on the surface of the magnetic nanoparticles, different levels of
nanoparticle clustering are achieved by changing the ionic force and
pH of the medium. Thus, the samples were submitted to two procedures
of EDL destabilization, which involved dilution with an alkaline solution
and a neutral pH viscous medium. The SPA results of all prepared ferrofluid
samples show a reduction of up to half the efficiency of the standard
sample when the ferrofluids are in a neutral pH or concentrated regime.
Such results are explained in terms of magnetic dipolar interactions.
Our results point to the importance of ferrofluid colloidal stability
in a more reliable experimental determination of the NP heat generation
performance.
Magnetic fluid hyperthermia (MFH), the procedure of raising the temperature of tumor cells using magnetic nanoparticles (MNPs) as heating agents, has proven successful in treating some types of cancer. However, the low heating power generated under physiological conditions makes necessary a high local concentration of MNPs at tumor sites. Here, we report how the in vitro heating power of magnetically soft MnFe2O4 nanoparticles can be enhanced by intracellular low-dimensional clusters through a strategy that includes: a) the design of the MNPs to retain Néel magnetic relaxation in high viscosity media, and b) culturing MNP-loaded cells under magnetic fields to produce elongated intracellular agglomerates. Our direct in vitro measurements demonstrated that the specific loss power (SLP) of elongated agglomerates (SLP=576±33 W/g) induced by culturing BV2 cells in situ under a dc magnetic field was increased by a factor of 2 compared to the SLP=305±25 W/g measured in aggregates freely formed within cells. A numerical mean-field model that included dipolar interactions quantitatively reproduced the SLPs of these clusters both in phantoms and in vitro, suggesting that it captures the relevant mechanisms behind power losses under high-viscosity conditions. These results indicate that in situ assembling of MNPs into low-dimensional structures is a sound possible way to improve the heating performance in MFH.
The prospect of combining both magnetic and plasmonic properties in one single nanoparticle promises both valuable insights on the properties of such systems from a fundamental point of view as well as numerous possibilities in technological applications. The combination of two of the most prominent metallic candidates, iron and silver, has, however, presented a lot of experimental difficulties because of their thermodynamic properties impeding miscibility or even coalescence. Here we present the thorough characterization of physically prepared Fe50Ag50 nanoparticles embedded in carbon and silica matrices by electron microscopy, optical spectroscopy, magnetometry and synchrotron-based x-ray spectroscopy. Iron and silver segregate completely into structures resembling fried eggs with a nearly spherical, crystallized silver part surrounded by an amorphous structure of iron carbide or oxide, depending on the environment of the particles. Consequently the particles display both plasmonic absorption corresponding to the silver nanospheres in an oxide environment as well as a reduced but measurable magnetic response. The suitability of such nanoparticles for technological applications is discussed in view of their high chemical reactivity with their environment.
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