1m/s from baseline(G3). The groups were similar by age and all risk factors. The baseline (154,8AE7,3/91,7AE10,2, 152,7AE12,1/92,3AE8,3 and 149,3AE8,1/91,7AE6,04mmHg) and achieved CBP (128,4AE7,26/80,1AE4,55, 125,6AE11,4/79,2AE6,5 and 126,6AE8,4/78,5AE5,97 mmHg) were similar. There was significant difference in baseline PWV (G1 15,9AE2,5 vsG2 13,6AE1,9 vsG3 10,9AE1,7 m/s,r<0.05), but at the end of the study PWV was similar: respectively,13,0AE2,1,13,6AE1,9 and 13,4AE1,9m/s. 72,7% pts in G1 and 66,7% in G2 received the highest recommended doses of RAAS-inhibitors and A10mg vs 28,6% in G3 (Pearsonc 2 Z9,0;r<0,05). Indapamide SR 1,5mg was added in 36,4%, 20% and 9,5%, respectively. Correlation and multiple regression analysis revealed the association between PWV decrease and doses of RAAS-inhibitors and amlodipine (rZ-0,5,bZ-0,45,p<0,05) Conclusion: There is modulating effect of target pressure achievement on PWV in hypertensive subjects. PWV reduction is associated with higher doses of RAAS inhibitors and amlodipine.Background: Pharmacokinetic modeling in Dynamic Contrast-Enhanced (DCE-)MRI has been introduced to non-invasively assess microvasculature in carotid atherosclerotic plaques, a marker for plaque vulnerability. The main model-parameter, K trans , can be assessed in the outer region of the vessel (adventitia) or in the entire vessel wall (including plaque and adventitia) and already showed association with histology and features of plaque vulnerability, respectively. We investigated systematically the correlation between K trans of these various regions of the vascular wall and their individual correlation with histology as gold standard. Methods: 45 symptomatic patients with 30-99% carotid stenosis underwent 3T DCE-MRI (0.1mmol/kg Gadobutrol, 0.5ml/sec). Quantitative modeling was performed to determine K trans of the entire vessel wall, adventitia, and plaque region, separately. For 10 patients, CD31 immunohistochemistry was performed on specimens (containing mainly plaque) removed during carotid endarterectomy to quantify the endothelial microvessel area. Results: Adventitial K trans showed weak correlation with plaque K trans (rZ0.64, p<0.001) and was 17.3% higher (p<0.001), coinciding with decreased uncertainty in parameter estimation (pZ0.015). Significant positive correlation between the endothelial microvessel area and adventitial K trans (rZ0.854, pZ0.002), but not from the plaque (rZ0.438, pZ0.2) was observed. Entire vessel wall K trans showed intermediate results for the various analyses. Discussion: Although K trans assessed over various regions within the vascular wall are correlated, absolute values differ significantly. Adventitial K trans seems to be a better measure for plaque microvasculature compared to other vascular regions, coinciding with a lower uncertainty in parameter estimation. Comparison with histology in a larger number of patients is recommended for definitive conclusions.
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