El hilah et al. J. Appl. Biosci. 2016 Étude ethnobotanique des plantes médicinales utilisées dans le traitement des affections dermatologiques dans le plateau central marocain ABSTRACT Objective: An ethnobotany study in Moroccan central plateau between 2010 and 2013 was set with the objective of evaluating the potential of the region on medicinal plants used in the treatment of Dermatological diseases. This study is a scientific evaluation of the potential medicinal plants, for better utilization of natural resources and the traditional knowledge.El hilah et al.
J. Appl. Biosci. 2016Étude ethnobotanique des plantes médicinales utilisées dans le traitement des affections dermatologiques dans le plateau central marocain 9253 Methodology and results: During each interview, all the information on the survey and the medicinal plant used was collected. The survey targeted 737 people from the local population with 559 were using medicinal plants (76.40%) and 178 people using modern medicine (23.60%). The population that cared for medicinal plants included 365 women (65.60%) and 194 men (34.40%), aged 10 to 90 years and all users of traditional medicine were illiterate and dominated with a percentage of 84.21%. Thus, the investigation identified 51 plant species grouped in 47 genera and 32 families belonging to the Lamiaceae, which were the majority, followed by the Myrtaceae, the Cactaceae and the Lythraceae. The leaves were used in the treatment of dermatological diseases. The remedies were prepared primarily in powder. Conclusion and application of results: This study shows the medicinal plants used in the treatment of dermatological complaints by the population of the Moroccan central plateau. These results constitute a source of very precious information for the area studied and for subsequent researches for the domains of the phytochemistry and pharmacology in order to search for new natural substance.
In our days, tuberculosis, whet ever its localization, became a curable disease. The cornerstone is a 6 month course of isoniazid, rifampicine and pyrazinamide. All of the three first line antituberculosis drugs may induce hepatic damage which may have negative consequences for treatment outcome. Several risk factors were associated with the development of antituberculosis- drug-induced hepatotoxicity (ATDH). A retrospective study was conducted from July 2014 to March 2015 regarding all therapeutic drug-monitoring requests sent to the Laboratory of Poison Control and Pharmacovigilance Centre of Morocco. 142 patients diagnosed with active tuberculosis were included in study. Plasma peak levels of isoniazid, rifampicin and pyrazinamide were analyzed in plasma samples after 2 to 3 hours of administration of anti-tuberculosis treatment. Logistic regression was used to identify the ATDH risk factors. The incidence of ATDH was found 24.6% (35 patients out of 142). Intergroup differences in the plasma levels were statistically significant for isoniazid (p=0.036). ATDH was found to be associated with combined form of anti-TB drugs (p=0.002, COR=13.1, AOR= 13.5) and plasma concentration of INH superior to 2mg/l (p=0.045, COR=1.3, AOR= 1.4).age, gender, alcohol intake and smoking status were not significantly associated with ATDH. The finding of 24.6% incidence of hepatotoxicity is extremely high. Many factors can be associated with the development of ATDH such as genetic factors, combined forms of treatment and plasma peak levels.
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