Background: Kbtbd5 is involved in skeletal muscle myogenesis, although the underlying mechanism is unclear. Results: Kbtbd5 interacts with DP1 and regulates the activity of E2F1-DP1 in skeletal muscle myogenesis. Conclusion: Kbtbd5 is an important regulator of skeletal muscle myogenesis through the regulation of E2F1-DP1 activity. Significance: This is the first report to identify DP1 as a substrate of Kbtbd5.
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