These analyses support the hypothesis that hyponatremia is a risk factor for osteoporosis and fracture. Additional studies are required to evaluate whether correction of hyponatremia will improve patient outcomes.

Human exposure to ionizing radiation (IR) disrupts normal metabolic processes in cells and organs by inducing complex biological responses that interfere with gene and protein expression. Conventional dosimetry, monitoring of prodromal symptoms, and peripheral lymphocyte counts are of limited value as organ- and tissue-specific biomarkers for personnel exposed to radiation, particularly, weeks or months after exposure. Analysis of metabolites generated in known stress-responsive pathways by molecular profiling helps to predict the physiological status of an individual in response to environmental or genetic perturbations. Thus, a multi-metabolite profile obtained from a high-resolution mass spectrometry-based metabolomics platform offers potential for identification of robust biomarkers to predict radiation toxicity of organs and tissues resulting from exposures to therapeutic or non-therapeutic IR. Here, we review the status of radiation metabolomics and explore applications as a standalone technology, as well as its integration in systems biology, to facilitate a better understanding of the molecular basis of radiation response. Finally, we draw attention to the identification of specific pathways that can be targeted for the development of therapeutics to alleviate or mitigate harmful effects of radiation exposure.

In order to investigate the process of noncovalent adsorption on glassy carbon surfaces, two terpyridine ligands 4-pyren-1-yl-N-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentyl]-butyramide (tpy~py) and N-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentyl]-2-naphthamide (tpy~nap) as well as the homoleptic cobalt(II) complexes of these ligands (Co(tpy~py)(2)(PF(6))(2) and Co(tpy~nap)(2)(PF(6))(2)) were synthesized. Electrochemical measurements in solution were used to characterize the transport behavior of these complexes and to verify that the polyaromatic portion of each ligand did not dramatically influence the electronic properties of the transition metal complex. The adsorption of the cobalt complexes above on glassy carbon electrode surfaces was then examined using cyclic voltammetry and was found to be well described by Langmuir or Frumkin isotherms. The free energy of adsorption for Co(tpy~py)(2)(PF(6))(2) was considerably larger than that for Co(tpy~nap)(2)(PF(6))(2): -41 versus -30 kJ/mol.

Chromosome 1q21.1 deletion syndrome is associated with a wide variety of clinical features including mild to moderate mental retardation, microcephaly, cardiac abnormalities, and cataracts. We report an unusual case of a premature neonate with persistent hyponatremia, markedly elevated plasma arginine vasopressin level (32.7 pg/mL), and clinical findings consistent with the syndrome of inappropriate antidiuretic hormone secretion (SIADH). The patient, who also had microcephaly and dextrocardia, was subsequently diagnosed with chromosome 1q21.1 deletion syndrome. Further evaluation revealed hypothalamic abnormalities, features not previously described with this syndrome. To our knowledge, this is the first report of SIADH associated with congenital hypothalamic anomalies in a neonate with chromosome 1q21.1 deletion syndrome. We also report our experience using tolvaptan, a vasopressin receptor antagonist, in this patient to effectively maintain eunatremia.

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