Androgens and women: COVID-19 outcomes in women with acne vulgaris, polycystic ovarian syndrome, and hirsutism Dear Editor, Disproportionately increased COVID-19 severity in men has resulted in investigation into androgen-regulated transcription of transmembrane protease-serine 2 (TMPRSS2), which mediates SARS-CoV-2 infectivity. 1 Several dermatologic disorders are associated with androgen excess, such as polycystic ovarian syndrome (PCOS), acne cystica, and hirsutism in women. 2 Considering the implication that androgens play a role in COVID-19 infection-related outcomes in men, we examined COVID-19 incidence and severity in women with these dermatologic conditions. The HIPAA-limited University of California COVID Research Data Set (UC CORDS) provides access to health records for patients tested for COVID-19 across UC medical institutions. 3 As of October 8, 2020, it had COVID-19 test results, demographics, hospitalization, and mortality on 117,529 women, age 0-65. Data on diagnoses of acne vulgaris, PCOS,
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