Benzene-I ,3-dicarboxaldehyde and diethylenetriamine have been condensed to produce a new 24-atom tetra Schiff base binucleating macrocyclic ligand in good yield; the latter forms a dinuclear Cul complex which combines with dioxygen and inserts one of the oxygen atoms into the 2-position of the aromatic ring to form a phenolate-and hydroxide-bridged binuclear copper(ii) complex.Proteins known to contain a dinuclear copper centre and bind dioxygenl include tyrosinase and dopamine-6-hydroxylase, which insert oxygen into organic substrates. Very little information is available on the structure of these mono-oxygenases, although tyrosinase is believed132 to be closely related to hemocyanin, whose structure is known. A number of synthetic models of tyrosinase , based on open-chain binucleating ligands, have been reported.2 Karlin et al.3 were the first to prepare such a model, consisting of a binucleating ligand which provides two pyridine and one aliphatic nitrogen
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