Chondrosarcoma is a malignant tumor occupying the 2nd position in terms of frequency, all ages combined, after osteosarcoma [1]. Epidemiological data extracted from cancer registries in Europe indicate an annual incidence of ~0.1/100,000 inhabitants [2]. Mesenchymal chondrosarcoma of bone is a rare high-grade variant of chondrosarcoma (2-13%), which usually has an extra-skeletal (30-40%) or central intramedullary location (15-30%).
Chondrosarcoma is the most common primary malignant bone tumor after myeloma and osteosarcoma, ranking third. It may be in second place in terms of frequency after osteosarcoma if we consider myeloma as a tumor of bone marrow cells rather than a bone tumor because it is a hematopoietic derivation [1].
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