Objectives: The goal of our study was to investigate the effect of male body mass index on serum anti-mullerian hormone (AMH) and outcome of intracytoplasmic sperm injection (ICSI) (fertilization rate, cleavage rate, embryo quality, total embryos and pregnancy rate). Patients and methods: A prospective cohort study was carried on fifty-five infertile couples who encountered inclusion criteria. Blood samples were analysed for AMH. Semen samples were collected and examined according to World Health Organization ,1999. Weight and height measurements were performed and patients were divided by BMI into normal weight (BMI 18.5-24.9 Kg/m²,n=21), overweight (BMI 25-29.9Kg/m²,n=22) and obese(BMI>30Kg/m²,n=12). Results: A negative correlation was found between BMI and serum level of AMH(r=-0.507,p=0.001).Fertilization rate, cleavage rate ,total embryo and pregnancy rate were found to be not related to BMI while the good quality embryo was a significantly high in normal weight men compared to overweight and obese men(6.47±0.96, 3.77±0.66, 2.75±0.66). Sperm concentration was found significantly high in normal weight men compared to overweight and obese men(39.90±6.06 million /ml, 24.73±6.14million/ml, 7.42±1.73 million /ml). Progressive sperm motility was also high in normal weight than overweight and obese men(47.67±4.53, 30.82±4.16, 15.67±4.01). No significant difference was found in sperm morphology among study groups. Conclusion: Our findings suggest that BMI may have a negative effect on the serum AMH level and semen parameters with no effect on ICSI outcomes except for good quality embryo.
Polycystic ovary syndrome (PCOS) is one of the major causes of decreased fertility in young females. Multiple extra- and intra-ovarian factors which are worked together or separately are responsible for sub-fertility. However, still, ovulatory dysfunction is the cornerstone that occurs as a result of hormonal dysfunction and consequently affects oocytes' quality, embryonic development and finally, implantation failure with a significant number of females seek assisted reproduction for getting pregnancy.
To evaluate the correlation between male serum anti-mullerian hormone and ICSI outcomes ( fertilization rate, cleveage rate, quality of embryos and pregnancy rate ). The type of study was controlled randomized study on fifty five infertile couples undergoing ICSI procedure at fertility center in Al-Sadder medical city in Al Najaf Al Ashraf. The research was included two groups are unexplained (n=24) and male factor infertility ( n=31)who underwent intracytoplasmic sperm injection programme. blood samples were taken from husbands to assessment of anti-mullerian hormone at day of retrieval of follicles. The results of ICSI were reported in both two groups. The correlation between male serum anti-mullerian hormone with fertilization rate, cleavege rate, and quality of embryos was studied. The current research results were revealed significant increase ( P <0.001), in concentration of male serum anti-mullerian hormone in unexplained group (7.29 ± 0.73) compared to male factor (2.36 ± 0.19 ) group. good quality embryos had significant increase (P value0.053)in unexplained group (5.70 ± 0.94) compared to male factor group(3.70 ± 0.5). Pregnancy rate was also found to be not significantly differed but the higher percentage of pregnancy (32.3%) occurred in male factor group compared to unexplained group(25%).There was positive correlation (r=0.293 p=0.03 ) between good quality embryos and male serum anti-mullerian hormone. Results of this study showed found positive correlation between male serum anti-mullerian hormone and good embryos which may lead to improvement in pregnancy rates.
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