activation, was significantly reduced in the REDD1 KO group compared to WT cells. Conclusions: These results demonstrate that REDD1 is a crucial mediator of inflammation and injury following liver I/R and implicate NF-kB as a downstream target through TLR4 signaling.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.