Administration of a high-protein diet providing 7-7.8 g of tryptophan per kg of the ration to rats with streptozotocin and alloxan diabetes mellitus resulted in development of a trend to increased liver content of nicotinamide coenzymes and in increased 1-methylnicotinamide excretion with the urine in both groups of animals, this reflecting increased niacin synthesis from tryptophan. Sugar-reducing effect of high-dose nicotinamide was not potentiated by increase of protein share in the ration. These results permitted the authors to suggest that intensification of endogenous niacin synthesis from tryptophan contained in the ration may be one of the mechanisms of a protective effect of high- protein diets in diabetes.
The authors present data- on the protective effect of newborn rabbits pancreatic islet cell culture xenotransplantation of Langerhans islets P-cells of rats with alloxan diabetes. This effect was the most marked in rats fed diets with normal or increased protein content. The authors discuss a possible stimulating effect of rabbit islet cell culture xenooransplantation on regeneration processes in recipient rat pancreatic islets. This effect was better pronounced in rats kept on rations with increased protein content. Further experiments will help more accuretaly define the indications for therapy of insulindependent diabetes mellitus by xenokansplantations of islet cell cultures.
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