Background:The overall view of erythropoiesis remains unclear. Results: Overexpression of ␣-1,6-fucosyltransferase inhibits hemoglobin production in murine and human erythroleukemia cells; down-regulation of ␣-1,6-fucosyltransferase promotes hemoglobin production and erythroid differentiation of human erythroleukemia cells. Conclusion: Core fucosylation plays an important role in hemoglobin production and erythroid differentiation. Significance: This might be the first finding that glycosylation negatively regulates erythroid differentiation.
The kinetics of structural relaxation in fragile glass former, Pd46Cu35.5P18.5 BMG, and strong glass former, Zr50Cu40Al10 BMG, was investigated by volume relaxation. The former exhibited a relaxation phenomenon that is well understood by the local topological instability model, while the latter showed monotonous relaxation behavior over a wide range down to Tg-60 K. The discrepancy may be closely related to the difference in the fragility of both glasses.
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