Postexposure conditioning, as a part of hormesis, involves the application of a low dose of stress following exposure to a severe stress condition. Depending on whether the low-dose stress is of the same type of stress or is different from the initial high-dose stress causing the diseased state, postconditioning can be classified as homologous or heterologous, respectively. In clinical homeopathy, the same distinction is found between isopathic and homeopathic application of low-dose substances. Homeopathy is unique for its Similia principle, which implies that substances causing symptoms in healthy biological systems can be used to treat similar symptoms in diseased biological systems. The evaluation of the Similia principle in an experimental set-up requires the analysis of a complex sequence of ‘damage-disease-treatment-effect’ events. The process of recovery from an insult is then monitored and a possible beneficial effect on this recovery process, upon application of a range of substances in low dose, can subsequently be analyzed using molecular and functional parameters. It is then possible to compare the effect of treatment with the degree of similarity between the diseased state and the effects caused by homologous and/or different heterologous substances. Beneficial effects of postconditioning mild stress conditions have been described in terms of an increase of the synthesis of stress proteins. In this commentary paper, we present additional information on this aspect. The experimental data suggest that the beneficial effect of the low-dose stress condition used as heterologous postconditioning is related to similarity in molecular stress response.

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SUMMARYI. Kinetic data on the repression, the derepression and the induction of ~-glucosidase synthesis in protoplasts of Saccharomyces carlsbergensis suggested that some site other than the stereospecific site for the induction by maltose was involved in the repression by glucose.2. A study of the effect of actinomycin D on the induced and noninduced (derepressed) synthesis of ~-glucosidase showed that induction by maltose caused mRNA to be synthesized. The mRNA coding for a-glucosidase synthesized during the first 12o min of induction appeared to be stable under conditions of both repression and derepression.3. During the phase of synthesis in which translation occurred only via the mRNA, glucose strongly affected 0~-glucosidase synthesis. Maltose did not exert any effect on translation.4. When both transcription and translation occurred, glucose inhibited transcription. However, translation and transcription were not affected to the same extent by glucose.

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