Retinopathy of prematurity (ROP) is a condition which is one of the major causes of preventable childhood blindness. ROP may develop in premature new-borns due to avascular or incompletely vascularized retina at birth which are prone to damage. The purpose of this study is to investigate the prevalence of retinopathy of prematurity (ROP), as well as its risk factors and severity, among newborns who were admitted to and screened at a tertiary care facility that serves a rural community.A cross-sectional study was conducted for a period of 1 year. All infants born prematurely who were admitted to the hospital and had a birth weight of less than or equal to 1500 g and/or less than 32 weeks of gestation were included in the study. Additionally, babies born between 1501-2500 grams and/or 33-35 weeks who were at a higher risk were also included. Under aseptic conditions all preterms were screened with RetCam in NICU of a tertiary hospital situated in rural area in Karnataka.224 preterm babies were screened for ROP. No ROP was noted in 185 babies (82.59%), 9 babies had stage 1 (4.02%), 21 babies stage 2 (9.38%), 9 babies had stage 3 ROP (4.02). No infant developed stage 4 and stage 5 ROP. Prevalence of ROP is 17.41% in our study. Low birth weight (LBW), Very low birth weight (VLBW), Respiratory Distress Syndrome and sepsis are found to be clinically significant in this study.In this study, the prevalence of ROP is 17.41%. LBW, VLBW, Respiratory Distress Syndrome and sepsis are found to significant risk factors. Early screening and timely appropriate treatment of ROP can prevent from causing childhood blindness.
Arch Dis Child 2012;97(Suppl 2):A1-A539 A55 AbstractsMethods 17 preterm infants with a median (IQR) gestational age of 26.6 (25.1-28.7) w, birth weight 924 (721-1240) g and postnatal age 136 (17.5-322) h were randomized to receive morphine (0.3 mg/kg).Blood samples for morphine, M6G and M3G concentrations were collected before administration, 20 min, 6 and 24 h after intubation. DNA was isolated from salivary swabs to genotype 18 polymorphisms in 12 genes using Taqman assays. Pain assessment (ALPS-0 and EDIN scales) was performed and additional morphine boluses were offered accordingly. The morphine level/pain score relation and the genotype influence on time to achieve a low pain score was calculated. Results In infants receiving no additional doses, clearance was 1.5-3.3 ml/kg/min in 5 infants of 5-34 h and 9.9 in one infant of 332 h postnatal age.Both morphine and morphine+M6G/5 correlated with mean ALPS-0 score at 6h (p=0.02 and 0.04) and 24 h (p=0.01 and 0.02). The COMT rs4680G>A (Val158Met) SNP was significantly correlated with time to reach the lowest pain score. COMT rs4680A patients experienced a faster response to opioids compared to rs4680GG patients in both groups (p=0.001 and p=0.072). Conclusions Morphine clearance is dependent on postnatal age in premature infants. Genotyping would improve individual dosing of opioids during NICU-care. ANALGESIA MODULATES CORTICAL RESPONSE TO PAINFUL PROCEDURES IN EXTREMELY PRETERM NEWBORN INFANTS
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