Aims: Evaluation of the effectiveness of orthodontic treatment of Class II malocclusion with the Twin-block appliance in children withβ-thalassemia major. Methods: The study was conducted with 49 patients with Class II malocclusion aged 10-14 years. The control group included 23 healthy patients. The main group included 26 patients with β-thalassemia major. Patients had received orthodontic treatment with a Twin-block appliance. The duration of orthodontic treatment was 1.5–2 years. Results: In both groups, a statistically significant increase in the SNB angle was observed. Subsequently, the ANB angle was normalized. The effective length of the maxilla growing and mandibular length increasing was observed. Overjet distance is decreased due to favorable torque changes. Pretreatment assessment revealed that overbite was smaller in children with β-thalassemia major. As the effect of orthodontic treatment, statistically, significant changes were observed on both overjet and overbite distances (p <0.001). Conclusions: Orthodontic treatment of β-thalassemia major of patients with Twin-block appliance in mixed dentition stage is effective in improving inter arch relationships and the orofacial functions.
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