The accuracy of height predictions at various ages based on five different methods (TannerWhitehouse mark I; Tanner-Whitehouse mark II; index of potential height; BayleyPinneau; Roche-Wainer-Thissen) was compared at yearly intervals with final height achieved in 32 boys (78 predictions) and 100 girls (227 predictions) with constitutionally tall stature. The boys were initially seen at a mean (SD) chronological age of 12.5 (3) years whereas the mean chronological age in girls was 11-8 (2.1) years.In tail boys Tanner-Whitehouse mark II gives a good estimation of final height up to the bone age of 13 years with a mean overestimation of 1 cm. The overestimation of final height is higher in the bone age groups 13-14 years (2-7 cm) and 14-15 years (3-4 cm) mainly due to the tail boys with a height greater than 3 SD scores. Up to the bone age of 12 years the final height is massively overestimated by the Bayley-Pinneau method but this method give relatively accurate estimations thereafter. The estimated confidence limits are large (±8 cm) for the two methods up to a bone age of 15 years.In tail girls the Tanner-Whitehouse mark II method was accurate from bone age nine to 12 years but overestimated final height in the bone age groups 12-13 years and 13-15 years by a mean of 1-8 and 1-4 cm respectively. The Bayley-Pinneau method overestimated final height in the bone age groups 12-14 years whereas the height predictions are accurate thereafter. Up to a bone age of 13 years the estimated confidence limits for the two methods are large, ±7 cm, but tend to improve thereafter.It is concluded that there is no best or most accurate method for predicting adult height in tail children. There are methods of first choice differing with respect to sex and bone age. In addition, correcting factors may improve their accuracy and correct their tendency to overestimate or underestimate adult height. (Arch Dis Child 1992;67:1357-62) In constitutionally tall children the prediction of adult height is a major parameter for deciding whether or not any treatment should be given. Methods of prediction of adult height are mainly based on growth data from children of normal stature selected more or less at random and followed from infancy to adulthood.'-6 To date only the Tanner-Whitehouse mark II equation has included samples oftall children.7 8 Thus applying standard equations for determining adult height to children with growth disorders may not give accurate results.If treatment is given an accurate prediction of adult height is an important element in monitoring its influence on growth and skeletal maturation. The evaluation of the extent to which any given treatment has reduced the adult height is based on the difference between the predicted and attained adult height. The criteria for a good prediction method are reasonable accuracy over a large age range, small prediction error, and, if possible, validity for tall and for normal children.This study was performed to investigate and re-evaluate retrospectively growth data deri...
'b.~orrelli,'A.~rin~,*~.~ambiaso$.~arinl,%.del B a l z o , D e p a r b w n t of P e d i a t r i c s , U n i v e r s i t y of B e r n , S w i t z e r l a n d D i Z G i T k .~a p p a ( I n t r o d . b y R . V i r d i s ) D E n d o c r i n~l o g y D p t . , B a m b i n o GesC H p t . ,Rome, I t a l y PEDICPION OF ADbLT HEIGET I N UNTREATED TALL C H I L D m ;VALIDITY OF DIFFERENT METHODS C h a i r o f A n d r o l o q y , "La S a p i c n z a a ' U n i v . , R o n $ e , I t a l y LfI-RR ANALOGUE TREATMENT OF CENTRAL PRECOCIOUS 170 predictions in 90 tall g i r l s ( a g e 7-17 y r s ) a n d 68 pred i c t i o n s in 31 tall boys ( a g e 8-18 y r s ) w e r e calculated by the f o l l o w i n g methods: B a y l e y -P i m e a u ( B P I , T a m e r M a r k I ( T I ) , T a n n e r M a r k I1 ( T 111, R c c h e -W a i n e r -T h i s s e n (RWT), I n d e x of P o t e n t i a l H e i g h t ( I P H ) , and c a t p a r e d to a t t a i n e d f i n a l h e i g h t .In tall girls T I give good p r e d i c t i o n s i n the bone age (BA) range from 9-16 y r s . T I1 o v e r e s t i m a t e firial h e i c j h t f r~n BA 12-16 yrs, the tables w i t h m o r e than 3 variables d o not i m p r o v e t h e results. B P overpredicts frcm PA. 12-15 yrs. R W a n d I P H are not s u i t a b l e for t a l l g i r l s a t a l l bone ages. I n t a l l boys T I and T I S qive good results up to the RA of 13 yrs. F r o m 13-16 yrs both methds o v e r e s t i m a t e f i n a l h e i g h t , specially i n the very t a l l b o y s ( h e i g h t 7 3 S D ) . I n &4 over 16 y r s T I and T I1 is not applicable giving p a r a d o x i c a l r e s u l t s . B P grossly overestin~ates up to the BP. of 1 2 y r s , o v e r e s t i m a t e s s l i g h t l y up to 16 yrs a n d is the best m e t h o d a f t e r the BA of 16 y r s . RWT and I P H u n d e r e s t i m a t e f k a l height up to the BA of 14 yrs, thereafter give acceptable r e s u l t s . E v a l u a t i o n of a n y growth i r i h i b i t i n g therapy m u s t t a k e i n account R e s u l t s glrls: Mean TBG w a s m a r k e d l y ~ncrcased ( 3 6 . 6 2 2 . 3 mg/1 ) , b u t m e a n T 4 rose o n l y s l l g h t l y ( 9 4 . 9 L 7 . 2 u g / l ) , t h e r e f o r e m e a n T4/TDG r a t l o w a s d e f l n l t e l y d m l n l s h c d ( 2 . 5 5 + 0 . 1 7 ) , d l r e c t l y d e t e r m i n e d f r e e T 4 I ~k e w l s e . R e s u l t s o f T 3 werc3 v a r l a b l e . A h l g h lncrease I n SHBG, CBG a n d C a n d a n o m l C/CBG ratlo w a s f o u n d . 139T H E EFrCCT OF SOMATOSTATIN ANALOGUE ( S f l C 2 0 1 / 9 9 5 ) IN A B O Y WITH GIGANTISM R 1 5 y e a r o l d boy p r e s e n t e d u i t h a h i s t o r y o f e x c e s s i v e g r o w t h a n d f r o n t a l h e a d a c h e s . t l e w a s 200cm t a l l ( t i t SDS 1 4 . 1 ) a n d h a d e vi d e n c e o f h y p o g o n a d i s m . S k e l e t a 1 a g e w a s 1 5 y r s . E M 1 s c a n r e v e a l e d a p i t u i t a r y t u m o u r w i t h s u p r a s e l l a r ~x t e n s i o n . G r o w t h h o r m o n e (Gil) l e v e l s d u r i n g s l e e p w e r...
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