Condensation of 9-aminoacridine with p-substituted aromatic aldehydes led to the synthesis of the corresponding azomethines at yields of 60 -78%. 9-Aminoacridine azomethines were found to have in vitro antituberculous activity against Mycobacterium tuberculosis H 37 R v at a concentration of 6.25 mg/ml.The wide use of acridine derivatives in medicine started with the discovery of the antimalarial properties of Acriquine and the antibacterial properties of ethacridine lactate [1]. Agents of the acridine group have antibacterial, antiparasite, antiviral, and antitumor activity [2,3]. Studies on the synthesis and design of new antiviral, antitumor, and antibacterial agents of the acridine series are currently being actively pursued [4,5]. Thus, with the aim of seeking biologically active substances, 9-aminoacridine was interacted with p-substituted aromatic aldehydes to synthesize the corresponding azomethines (Scheme 1). 577 0091-150X/08/4210-0577
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