Chiral a-(O-carbamoyl)alkyl-and a-(N-carbamoyl)alkylcopper(I) reagents derived from (-)-sparteine-mediated asymmetric lithiation of hindered carbamates react with cationic h 3 -allylmolybdenum complexes with retention of configuration.
Aptamers, also known as chemical antibodies, are short single-stranded DNA, RNA or peptide molecules. These molecules can fold into complex three-dimensional structures and bind to target molecules with high affinity and specificity. The nucleic acid aptamers are selected from combinatorial libraries by an iterative in vitro selection procedure known as systematic evolution of ligands by exponential enrichment (SELEX). As a new class of therapeutics and drug targeting entities, bivalent and multivalent aptamer-based molecules are emerging as highly attractive alternatives to monoclonal antibodies as targeted therapeutics.Aptamers have several advantages, offering the possibility of overcoming limitations of antibodies: 1) they can be selected against toxic or non-immunogenic targets; 2) aptamers can be chemically modified by using modified nucleotides to enhance their stability in biological fluids or via incorporating reporter molecules, radioisotopes and functional groups for their detection and immobilization; 3) they have very low immunogenicity; 4) they display high stability at room temperature, in extreme pH, or solvent; 5) once selected, they can be chemically synthesized free from cell-culturederived contaminants, and they can be manufactured at any time, in large amounts, at relatively low cost and reproducibly; 6) they are smaller and thus can diffuse more rapidly into tissues and organs, leading to faster targeting in drug delivery; 7) they have lower molecular weight that can lead to faster body clearance, resulting in a low background noise for imaging and minimizing the radiation dose to the patient in diagnostic imaging. Thus, the high selectivity and sensitivity, ease of screening and production, chemical versatility as well as stability make aptamers a class of highly attractive agents for the development of novel therapeutics, targeted drug delivery vehicles and molecular imaging.In the review, we will discuss the latest technological advances in developing aptamers, its application as a novel class of drug on its own, as well as in surface functionalization of both polymer nanoparticles or nanoliposomes in the treatment of cancer, viral and autoimmune diseases.
Studies of the Hurwitz Group at the northeast end of the Rankin-Ennadai belt have disclosed a pocket of older pyritic, mildly radioactive sedimentary rocks similar to those farther west at Montgomery Lake. Basic data on these and associated rocks are presented
along with a figure showing the distribution of these rocks in the Padlei map-area. The lower formations of the Hurwitz Group are formally defined: Padlei Formation, Kinga Formation, including Maguse and Whiterock Lake Members, and Ameto Formation, including Happotiyik
Member.
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