Rituximab was effective in treating pemphigus vulgaris, was significantly better than conventional treatment, decreased the need for additional steroids and other immunosuppressants and induced prolonged remission. Rituximab was more effective when given early in the disease process. Further studies may highlight the need for additional cycles of rituximab to maintain sustained remission.
Progeria, also known as Hutchinson-Gilford syndrome, is an extremely rare, severe genetic condition wherein symptoms resembling aspects of aging are manifested at an early age. It is an autosomal dominant disorder. It is not seen in siblings of affected children although there are very few case reports of progeria affecting more than one child in a family. Here we are presenting two siblings, a 14-year-old male and a 13-year-old female with features of progeria, suggesting a possible autosomal recessive inheritance.
<p class="abstract"><strong>Background:</strong> Narrow band UVB phototherapy (NBUVB) is considered one of the most effective therapeutic modalities for patients with psoriasis. The long term side effects of narrowband UVB therapy have not been fully documented. There has been a great deal of interest in photo combination therapies that are capable of both reducing cumulative UVB doses and accelerating resolution of skin lesions. The aim of our study was to compare the efficacy and tolerability of NBUVB plus tazarotene combination therapy with NBUVB mono therapy.</p><p class="abstract"><strong>Methods:</strong> Forty patients with chronic plaque type psoriasis were taken up for the study and were randomly divided into two groups of 20 each. One group was treated with thrice-weekly NBUVB phototherapy and the other group received NBUVB phototherapy thrice weekly in addition to topical tazarotene once daily at bed time.<strong></strong></p><p class="abstract"><strong>Results:</strong> In the tazarotene combination group, the reduction in PASI score was more rapid. The duration of treatment and the mean cumulative dose of NBUVB was lesser in the tazarotene combination group. Irritation due to tazarotene was mild and combination of tazarotene with NBUVB was well tolerated.</p><p><strong>Conclusions:</strong> We concluded that combination of tazarotene with NBUVB was well tolerated and was significantly more effective than NBUVB phototherapy alone. </p>
<p class="abstract"><strong>Background:</strong> Prevalence of lichen planus (LP) and generalised lichen planus (GLP) is about 2.6% and 1% respectively. Various studies have shown higher prevalence of Diabetes Mellitus (DM) and stronger association between Hepatitis-C virus (HCV) and LP<strong>. </strong>The main objective of this study was to predict the prevalence of DM and HCV in patients with GLP before starting steroids.</p><p class="abstract"><strong>Methods:</strong> A case-control study was conducted with 33 patients in each group for one year period. Case group included patients with GLP excluding oral LP and drug induced lichenoid dermatitis. Control group included patients with other skin conditions and not on steroids. Preliminary details and history of DM and HCV were collected. Random blood sugar and Anti-HCV were done.<strong></strong></p><p class="abstract"><strong>Results:</strong> The proportion of patients with GLP was higher in women compared to men (63.6% vs. 36.3%). Highest prevalence was observed in the age group 35-45 years for both genders. On stratification by sex, odds of having GLP in women are 0.76 times lower among diabetics compared to non-diabetics whereas no association in males. There was no association between GLP and HCV in both sexes.</p><p class="abstract"><strong>Conclusions:</strong> There is no significant association between Diabetes mellitus and Hepatitis-C infection with GLP. Future study is planned with larger sample size for a definite conclusion.</p>
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.