Drug therapy problems are significant for the pharmaceutical care practitioner. The evaluation of drug therapy problems is the target of the assessment and shows the major decisions made in that step of the patient care process. Although drug therapy problem evaluation is technically part of the assessment procedure, it performs the very particular input made by pharmaceutical care practitioners. The prospective observational study was conducted at the Cardiology department with 450 hypertension patient based on Inclusion and exclusion criteria. The data collection form was administered after getting the Consent form. The data were analyzed by using SPSS software. A total of 450 HTN patients were included in the study & only 402 patients of them enrolled in the study as per the inclusion & Exclusion criteria stated in the protocol. In this study, 452 Interventions were performed & documented for both drug therapy 35.84% (n=162) & health education 64.15% (n=290). These interventions were equally distributed among the patients. Drug therapy-related intervention was solved amid adjustment of medication chart in HTN patients. The study sealed that pharmaceutical care Intervention is a basic device to enhance BP management in HTN patients. The role of Clinical pharmacist is essential to improve the knowledge of patient for better treatment outcome.
India is known for its traditional medicinal system – Ayurveda, Siddha and Unani. There are several references in our ancient literature about the miraculous curing properties of the plant-based drugs. “Rig Veda and Atharva veda” seems to be the earliest record of use of plant in the medicine. A stomach ulcer involves an erosion in a person’s gastrointestinal tract. ‘Peptic’ is derived from Greek word “Peptikos” who’s meaning is related to digestion. Peptic ulcer occurs in the part of the gastrointestinal track which is exposed to gastric acid and pepsin (i.e) the stomach and duodenum. The extract of Tephrosia purpurea flowers against viruses and is very good antibacterial against Gram +ve and Gram -ve strain. The Plant extract was prepared and the phytochemical analysis was performed. The extract was administered with animals. The drug were administered orally once daily for 2 days and 45 min prior to pyloric ligation. The animals are sacrificed after four hours of pylorus ligation. The result indicates that, Flavonoids and Tannins have shown to be present in the TPAL treated groups. Since flavanoids antagonize aggressive factor which play a decisive role in the pathogenesis of gastric lesion and also enhance defence factor to protect the gastric mucosa from injury. Flavanoids diminish histamine secretion from mast cell by inhibition of histidine decarboxylase and stimulate PG biosynthesis. So the antiulcer activity of TPAL may be attributed to its flavonoid content. The study concluded that TPAL has an anti ulcer activity which may be due to protection and the strengthening of the mucosal defensive factor like mucus, bicarbonate, prostaglandin.
Quercetin, rutin, silibinin three flavonoids are the major flavonols taken in diet. Among these, Quercetin has many benefit but it is poor soluble in water, unstable in gastric fluids which leads to lower therapeutic value and bio-availability. Hence to increase the therapeutic efficacy and bio-availability, quercetin loaded anionic polymeric nanoparticulate system have been developed using nanoprecipitation methods. Quercetin loaded Nanoparticulate systems were employed Characrization studies like size of particles, morphology, in–vitro drug releases and storage stability. This research result was revealed that a mean size of particle was 84.4 nanometer (nm) with Polydispersity Index was 0.268 and potential of 10.2 milli volt (mV), morphological studies shown formulated quercetin polymeric nanoparticles were sphere-shaped. The invitro drug releases studies shown >95% release of drugs within 45 mins. This novel approach of nanocomposite may promise a original system for the safeguard and release of a range of water hating chemicals to target specific tissues using specialized drug delivery.
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