Increase in population has affected many socio-economic conditions of people by increasing crimes, illiteracy, destructive activities, diseases, improper food and shelter. Thus to control this population and limit the family size at a personal level and at a national level, modern contraceptive methods and medicines were introduced long back. There are many new contraceptives available now, but they have various side effects. Some traditional practitioners used to dispense oral contraceptives mentioned in Ayurvedic classics. Such as 1) Pippali (Piper longum), Vidanga (Emblica ribes) and Tankana (Sodii Biboras). 2) Talisapatra (Taxus baccata) and Gairika (Hematite) with cold water and 3) Kanji bhavita Japakusuma (Hibiscus rosa sinensis). An experimental study on above mentioned 1 and 2 formulations has proved its efficacy as temporary contraceptive medicine. To evaluate the permanent or long term temporary contraceptive effect of Japakusuma, an attempt was made in this study. Study was conducted by Choudary and Khanna method on 18 female, 36 male (for mating) albino rats. Japakusuma, Propylene glycol, Ovral L formed the materials. Single dose was administered on proestrous stage of rat oestrous cycle and observed for anti-implantation and pregnancy interruption activity. Test drug showed significant anti implantation and pregnancy interruption activity. Thus showing the temporary contraceptive activity of Japakusuma (Hibiscus rosa sinensis).
Murchana Samskara (processing of ghee) is mentioned in Bhaishajya Ratnavali for both Taila (oil) and Ghrita Kalpana (ghee formulations) to reduce Amadosa, Durgandhata (bad odour) etc. Dosha (impurities) and to enhance the Viryata (potency) of Sneha (lipid). Physico-chemical analysis of Murchita Ghrita (processed ghee) sample has shown increase in the specific gravity, saponification value, Iodine value, Ester value, total fatty acids and decrease in acid value, viscosity, Density etc. Murchana process imparts changes in good colour, odour, minimizing rancidity & increasing stability facilitates better dissolution of bio constituents in Ghrita (ghee). So, to evaluate the changes after Murchana with advanced method GC-MS study. The samples of Amurchita (plain ghee) and Murchita Ghrita (processed ghee) were subjected for analysis. In GC-MS study Ghrita (ghee) sample shown increase in number of unsaturated fatty acids like oleic acid, gondoic acid, 9,12-Octadecadienoic acid (Z,Z) methyl ester etc may contribute increase in HDL Cholesterol and decrease in LDL Cholesterol. Other effects of Murchana Samskara (processing of ghee) are beneficial in decreasing risk of developing cardiovascular diseases, advantageous in impact on metabolism, in reducing risk of male infertility & growth retardation and addition of new components.
Abnormal food habits (mithyaahara), abnormal style of living (mithyavihara), and other factors disturbs Jatharagni, which leads to jwara (fever) &vedana (pain). Bruhat Hinguleshwara Rasa is mentioned in Bhaisajya Ratnavali, having a multidimensional therapeutic indication i.e. Jwarahara and Vedananashak& this activity have encouraged to evaluate the antipyretic activity. Albino rats were divided into three groups and distributed 06 in each group. Test drug (Group-I), Standard drug (Group-II) and Group-III (Propylene glycol).Anti-pyretic study was done by Yeast induced method. Significant antipyretic activity was observed in Test Drug (GI), and Standard Drug (GII). But in Test Drug (GI) it was highly significant than Control Drug (GIII). In test drug antipyretic activity was observed from 1st hr to 6th hr, while in standard it was fr om 1st hr to 5th hr. Bruhat Hinguleshwara Rasa has shown significant and sustained Anti-pyretic Activity. This study has provided evidence& given scope for clinical research.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.