Injuries to children arising from home accidents are an increasing community health concern. The aim of this cross-sectional study in Qalubeya governorate, Egypt was to measure the incidence and types of home injuries affecting rural children aged up to 12 years and to assess their mothers' knowledge, attitudes and practices (KAP) about first aid and its associated factors. An interview questionnaire was completed by 1450 rural mothers. The incidence of home injuries in the previous 4 weeks was 38.3% (57.5% were boys). Cut wounds, falls and fractures, burns, poisoning and foreign body aspiration were the common forms of home injuries. Mothers answered an average of 11.0 (SD 5.3) out of 29 KAP questions correctly. Younger age of mother, higher level of education, higher socioeconomic status, being in paid employment, source of knowledge about first aid and having attended a training course on first aid were significant predictors of better KAP among mothers.