The term 'female sexual dysfunction' (FSD) encompasses a number of different disorders, and while their aetiologies are not fully understood, the sub-classifications of this broad umbrella term are increasingly becoming more established and accepted. However, there is less consensus regarding the optimal treatment of these conditions. While it is known that phosphodiesterase (PDE5) is involved in the female sexual response, the clinical and research evidence supporting the unlicensed use of PDE5 inhibitors (PDE5i) in women is inconclusive and at times contradictory. In this article we explore this further by means of a comprehensive literature review on the use of PDE5i in the treatment of FSD and we also present our clinical experience of using these drugs in this context.
Ever since Willstdtter synthesized a-cocaine (I) in 1896, his statement that it did not possess local anaesthetic properties has been accepted, although his only evidence was that it did not have the numbing effect on the tongue characteristic of cocaine. a-Cocaine is a structural isomer of cocaine (II) and is closely related in structure to a-eucaine (III), one of the earliest synthetic local anaesthetics; consequently it is difficult to understand why WillstAtter's statement was accepted CH2-CH-CH2--
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.