Change in diet life style and increased life expectancy has led to the dramatic escalation in old age related complication like cognitive decline leading to dementia. Cardiovascular diseases (CVD) are huge risk factors for dementia, including Alzheimer disease (AD). Hypertension is very well known to cause cognitive impairment. Control of CVD could provide protection against dementia. Earlier in the mouse model of AD, reserpine, an antihypertensive and antipsychotic drug could elicit improvement in the working memory in AD model mice and enhance the same in normal mice. Hence, Cognitive protection in the patients on chronic antihypertensive drug which contains reserpine was evaluated. Cognition in a cohort (in the South Indian rural population) of hypertensive patients (majority age group 50 to 70 years) who have been chronically treated with a combinatorial drug(adelphane/adelphane esidrexsodl by Novaritis Switzerland) consisting of reserpine and hydrazine for years was compared with controls without hypertension. The cohorts were age sex socio-economic education background matched. Cognition was scored using the Tamil version of: Addenbrooke Cognitive Examination-III (ACEIII (Tamil)) and Montreal Cognitive Assessment (Tamil) scales. The composite ACEIII (Tamil) score of control and treated groups were 53.6 and 53.2 respectively. MoCA(tamil) scores (Control :15.1 and Treated: 14.7) did not show much alteration. Further the mean scores of the control and treated groups individual components of cognition in ACE, namely Attention Memory Fluency Language and visuospatial cognitive skills also did not reveal significant difference. Thus controlling blood pressure or hypertension with chronic antihypertensive medication like adelphane/adelphane esirdex (reserpine containing drugs) has retained normal cognition in both genders.
The use of nanoparticles in concrete increases the material’s strength and durability, making it useful in the building sector. Nanomaterials can lower the amount of cement in a building since cement releases carbon dioxide, which contributes to global warming. The mechanical response of concrete is studied in this study by replacing cement with various dosages of nanotitanium dioxide and nanoalumina. Nanotechnology has attracted a lot of attention in recent years because of its potential uses for particles. Cementitious materials at the nano/atomic level are the primary focus of current research. The mechanical characteristics of cementitious materials have been significantly improved by introducing nanotitanium dioxide and nanoalumina into cement. Nanotitanium dioxide and nanoalumina have been added to concrete in this study to examine its sorptivity and water absorption properties. To lower the carbon footprint of concrete, nanotitanium dioxide and nanoalumina can be used in place of cement.
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